CD4 and CD38

Data Source:
HPRD (in vitro)

		CD4	CD38
Description		CD4 molecule	CD38 molecule
Image
GO Annotations	Cellular Component	Early Endosome Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Membrane Raft	Nucleus Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Secretory Granule Membrane Extracellular Exosome
	Molecular Function	Virus Receptor Activity Transmembrane Signaling Receptor Activity Extracellular Matrix Structural Constituent Protein Binding Zinc Ion Binding Coreceptor Activity Immunoglobulin Binding Enzyme Binding Protein Kinase Binding MHC Class II Protein Complex Binding Signaling Receptor Activity Interleukin-16 Binding Interleukin-16 Receptor Activity MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Tyrosine Kinase Binding	NAD+ Nucleosidase Activity Transferase Activity Phosphorus-oxygen Lyase Activity Identical Protein Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Positive Regulation Of Protein Phosphorylation Adaptive Immune Response Induction By Virus Of Host Cell-cell Fusion Immune Response Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Calcium Ion Transport Into Cytosol Fusion Of Virus Membrane With Host Plasma Membrane Cytokine-mediated Signaling Pathway T Cell Differentiation Macrophage Differentiation Response To Estradiol Maintenance Of Protein Location In Cell Positive Regulation Of Interleukin-2 Production Response To Vitamin D Positive Regulation Of Kinase Activity Helper T Cell Enhancement Of Adaptive Immune Response Interleukin-15-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade T Cell Selection Positive Regulation Of Monocyte Differentiation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Entry Into Host Cell Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Positive Regulation Of Calcium-mediated Signaling T Cell Receptor Signaling Pathway Regulation Of T Cell Activation Regulation Of Calcium Ion Transport Membrane Organization Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus	Response To Hypoxia Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Female Pregnancy Negative Regulation Of Neuron Projection Development Artery Smooth Muscle Contraction NAD Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Insulin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Hydroperoxide Response To Drug Negative Regulation Of Apoptotic Process Negative Regulation Of Bone Resorption Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction B Cell Receptor Signaling Pathway Long-term Synaptic Depression Response To Interleukin-1 Apoptotic Signaling Pathway
Pathways		Alpha-defensins Nef Mediated CD4 Down-regulation Binding and entry of HIV virion Vpu mediated degradation of CD4 Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Other interleukin signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Nicotinate metabolism
Drugs		Antithymocyte immunoglobulin (rabbit) Clenoliximab Ibalizumab	Daratumumab Isatuximab Mezagitamab
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Response to Vitamin E supplementation ( 22437554)	Blood protein levels ( 28240269) Neurological blood protein biomarker levels ( 31320639) Parkinson's disease ( 27182965 28892059)
Interacting Genes		38 interacting genes: ABCB1 ADRB2 CCR5 CD2 CD28 CD38 CD44 CD5 CD53 CD82 CTSD CXCL12 CXCR4 DPP4 FCGR3A HLA-DPA1 HLA-DQA2 HLA-DQB1 IL16 IL2RA INPPL1 KCNAB2 LAT LCK LGALS1 MAPK14 MARCHF4 PI4KA PIK3R1 PIP PTPRC SELL SIVA1 SPG21 TFRC TNFRSF10A UBL7 UNC119	6 interacting genes: CBL CD4 CD9 FCGR3A LCK PECAM1
Entrez ID		920	952
HPRD ID		01740	00116
Ensembl ID		ENSG00000010610	ENSG00000004468
Uniprot IDs		A0A4Y5UGE4 B0AZV7 B4DT49 P01730	B4E006 P28907
PDB IDs		1CDH 1CDI 1CDJ 1CDU 1CDY 1G9M 1G9N 1GC1 1JL4 1OPN 1OPT 1OPW 1Q68 1RZJ 1RZK 1WBR 1WIO 1WIP 1WIQ 2B4C 2JKR 2JKT 2KLU 2NXY 2NXZ 2NY0 2NY1 2NY2 2NY3 2NY4 2NY5 2NY6 2QAD 3B71 3CD4 3J70 3JCB 3JCC 3JWD 3JWO 3LQA 3O2D 3S4S 3S5L 3T0E 4H8W 4JM2 4P9H 4Q6I 4R2G 4R4H 4RQS 5A7X 5A8H 5CAY 5THR 5U1F 5VN3 6CM3 6EDU 6L1Y 6MEO 6MET 6OPN 6OPO 6OPP 6OPQ 6QH6 6QH7 6U0L 6U0N 6URI 6X5B 6X5C	1YH3 1ZVM 2EF1 2HCT 2I65 2I66 2I67 2O3Q 2O3R 2O3S 2O3T 2O3U 2PGJ 2PGL 3DZF 3DZG 3DZH 3DZI 3DZJ 3DZK 3F6Y 3I9M 3I9N 3OFS 3RAJ 3ROK 3ROM 3ROP 3ROQ 3U4H 3U4I 4CMH 4F45 4F46 4OGW 4TMF 4XJS 4XJT 5F1K 5F1O 5F21 6EDR 6VUA
Enriched GO Terms of Interacting Partners?
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