DDX21 and H2AX

Data Source:
BioGRID (pull down)

		DDX21	H2AX
Description		DExD-box helicase 21	H2A.X variant histone
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GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Mitochondrion Cytosol Membrane	Chromosome, Telomeric Region Nucleosome Condensed Nuclear Chromosome Male Germ Cell Nucleus XY Body Nucleus Nucleoplasm Replication Fork Centrosome Nuclear Speck Site Of Double-strand Break Extracellular Exosome Site Of DNA Damage
	Molecular Function	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding	DNA Binding Damaged DNA Binding Protein Binding Enzyme Binding Histone Binding Protein Heterodimerization Activity
	Biological Process	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus R-loop Disassembly	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Nucleosome Assembly Chromatin Silencing Cellular Response To DNA Damage Stimulus Spermatogenesis Response To Ionizing Radiation Viral Process Cerebral Cortex Development Positive Regulation Of DNA Repair Meiotic Cell Cycle Cellular Response To Gamma Radiation Cellular Senescence
Pathways		B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)
Interacting Genes		87 interacting genes: CALM1 CSNK2A1 DUX4 ERG H2AX IL7R JUN KPNA3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PIAS1 PTEN SRPK2 SUMO2 TERF1 TERF2 UBE2I	46 interacting genes: A2M ACTB ALG9 ATM ATR BARD1 BMI1 BRCA1 BRCA2 BRD1 CALM1 COPG1 DDX21 DHX9 EYA1 HUWE1 KAT5 MASP1 MDC1 MRE11 NBN NCL NGFR OTUB1 PAXIP1 PBK PPP1CA PRKDC PTPA QARS1 RNF168 RNF8 RPS6KA3 SMARCA4 SSRP1 SUPT16H SUPT5H TAF1C TAF5L TERF2 TIAM2 TOPORS TP53BP1 TRAF6 TSSK6 WRN
Entrez ID		9188	3014
HPRD ID		05895	03465
Ensembl ID		ENSG00000165732	ENSG00000188486
Uniprot IDs		Q9NR30	P16104
PDB IDs		2M3D 6L5L 6L5M 6L5N 6L5O	1YDP 2AZM 2D31 2DYP 3SHV 3SQD 3SZM 3U3Z 6K1I 6K1J 6K1K
Enriched GO Terms of Interacting Partners?
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