DDX21 and PNMA2

Data Source:
BioGRID (two hybrid)

		DDX21	PNMA2
Description		DExD-box helicase 21	PNMA family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Mitochondrion Cytosol Membrane	Nucleolus
	Molecular Function	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding RRNA Binding SnoRNA Binding MiRNA Binding Identical Protein Binding 7SK SnRNA Binding	Protein Binding
	Biological Process	Osteoblast Differentiation Positive Regulation Of Myeloid Dendritic Cell Cytokine Production RRNA Processing Transcription By RNA Polymerase II Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Gene Expression, Epigenetic Defense Response To Virus R-loop Disassembly	Positive Regulation Of Apoptotic Process
Pathways		B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Depression (quantitative trait) ( 20800221)	Brain morphology (MOSTest) ( 32665545) Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		87 interacting genes: CALM1 CSNK2A1 DUX4 ERG H2AX IL7R JUN KPNA3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PIAS1 PTEN SRPK2 SUMO2 TERF1 TERF2 UBE2I	32 interacting genes: BYSL CBX8 CCDC33 CDC37 CNNM3 ENKD1 FAM161A GPATCH2L HAPLN2 INO80B LRR1 MISP MORF4L2 NTAQ1 PPIG PRPF31 PSMA1 RNF6 RNF8 RPL9 RTP5 SCNM1 SDCBP THAP7 TOP3B TTLL10 ZNF408 ZNF417 ZNF587 ZNF669 ZNF688 ZNF785
Entrez ID		9188	10687
HPRD ID		05895	04915
Ensembl ID		ENSG00000165732	ENSG00000240694
Uniprot IDs		Q9NR30	Q5U5Z3 Q9UL42
PDB IDs		2M3D 6L5L 6L5M 6L5N 6L5O
Enriched GO Terms of Interacting Partners?
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