LPAR2 and ARHGEF12

Data Source:
HPRD (in vivo, in vitro)

		LPAR2	ARHGEF12
Description		lysophosphatidic acid receptor 2	Rho guanine nucleotide exchange factor 12
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle	Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Lipid Binding Lysophosphatidic Acid Receptor Activity	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Metabolic Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Schizophrenia ( 23974872) Sphingolipid levels ( 22359512)	Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778 30104761) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105) Height ( 31562340) Intraocular pressure ( 29617998 25637523 31798171 29785010 31959993 30054594 28073927 29235454) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: ARHGEF11 ARHGEF12 ATXN1 GIPC1 SLC9A3R1 SLC9A3R2 TRIP6	17 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC
Entrez ID		9170	23365
HPRD ID		05487	09207
Ensembl ID		ENSG00000064547	ENSG00000196914
Uniprot IDs		A0A024R7M9 Q9HBW0	B4E2K6 E9PMR6 Q9NZN5
PDB IDs		4P0C	1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?
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