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CD3E and MUC15
Data Source:
BioGRID
(two hybrid)
CD3E
MUC15
Description
CD3e molecule
mucin 15, cell surface associated
Image
No pdb structure
GO Annotations
Cellular Component
Immunological Synapse
Endoplasmic Reticulum
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
External Side Of Plasma Membrane
T Cell Receptor Complex
Alpha-beta T Cell Receptor Complex
Dendritic Spine
Cell Body
Extracellular Region
Golgi Lumen
Plasma Membrane
Integral Component Of Membrane
Molecular Function
Transmembrane Signaling Receptor Activity
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Signaling Receptor Complex Adaptor Activity
T Cell Receptor Binding
Identical Protein Binding
Protein Heterodimerization Activity
Protein Binding
Biological Process
Positive Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
Positive Regulation Of T Cell Anergy
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
G Protein-coupled Receptor Signaling Pathway
Response To Nutrient
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Dendrite Development
Cerebellum Development
T Cell Costimulation
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of T Cell Proliferation
T Cell Activation
Regulation Of Apoptotic Process
Positive Thymic T Cell Selection
Negative Thymic T Cell Selection
Negative Regulation Of Smoothened Signaling Pathway
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Immune Response
Positive Regulation Of Calcium-mediated Signaling
T Cell Receptor Signaling Pathway
Protein-containing Complex Assembly
Apoptotic Signaling Pathway
Stimulatory C-type Lectin Receptor Signaling Pathway
O-glycan Processing
Pathways
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC)
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)
Defective GALNT12 causes colorectal cancer 1 (CRCS1)
Dectin-2 family
O-linked glycosylation of mucins
Termination of O-glycan biosynthesis
Drugs
Muromonab
Catumaxomab
Diseases
T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS
Lung cancer in ever smokers (
28604730
)
Pulse pressure (
27841878
)
Cerebrospinal fluid p-tau levels in Alzheimer's disease dementia (
29274321
)
Exhaled nitric oxide levels (
28109725
)
Exhaled nitric oxide output (
28109725
)
Obesity (extreme) (
19553259
)
Interacting Genes
26 interacting genes:
ADAM33
BNIP3
CD3D
CD3G
CD79B
CSK
EPS8L1
LCK
MUC15
NCK1
NCK2
NCL
PIK3R1
PKMYT1
POLR1G
PTPN22
SHC1
SNTA1
SYK
TOP2B
TRAT1
TRB
UBASH3A
UNC119
ZAP70
ZFPL1
2 interacting genes:
CD3E
CNR2
Entrez ID
916
143662
HPRD ID
08923
16349
Ensembl ID
ENSG00000198851
ENSG00000169550
Uniprot IDs
P07766
A0A0A0MT67
A0A0A0MTD6
Q8N387
PDB IDs
1A81
1SY6
1XIW
2ROL
5QU2
6JXR
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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