DYRK1B and GSC2

Data Source:
BioGRID (two hybrid)

		DYRK1B	GSC2
Description		dual specificity tyrosine phosphorylation regulated kinase 1B	goosecoid homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Chromatin Nucleus
	Molecular Function	Transcription Coactivator Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Phosphorylation Myoblast Fusion Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Adipose Tissue Development	Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Macular thickness ( 30535121)	Metabolite levels ( 22916037)
Interacting Genes		12 interacting genes: DCAF7 GSC2 HDAC5 ID2 MAP2K3 MAPK1 MAPK14 MBP PAK1 PCBD1 RANBP9 TROAP	60 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587
Entrez ID		9149	2928
HPRD ID		05188	03506
Ensembl ID		ENSG00000105204	ENSG00000063515
Uniprot IDs		A0A024R0I0 A0A024R0J6 A0A024R0M8 Q9Y463	O15499
PDB IDs
Enriched GO Terms of Interacting Partners?
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