INA and GRIN2D

Data Source:
HPRD (in vivo)

		INA	GRIN2D
Description		internexin neuronal intermediate filament protein alpha	glutamate ionotropic receptor NMDA type subunit 2D
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Neurofilament Cytoplasmic Ribonucleoprotein Granule Schaffer Collateral - CA1 Synapse Postsynapse	Plasma Membrane Integral Component Of Plasma Membrane NMDA Selective Glutamate Receptor Complex Postsynaptic Density Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton	Ionotropic Glutamate Receptor Activity NMDA Glutamate Receptor Activity Protein Binding Ligand-gated Ion Channel Activity Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity
	Biological Process	Substantia Nigra Development Cell Differentiation Neurofilament Cytoskeleton Organization Postsynaptic Actin Cytoskeleton Organization Postsynaptic Intermediate Filament Cytoskeleton Organization Cellular Response To Leukemia Inhibitory Factor	Startle Response Brain Development Adult Locomotory Behavior Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission
Pathways			Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs			Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Memantine Orphenadrine Phenobarbital Aripiprazole Tenocyclidine Prasterone Milnacipran Acetylcysteine Ketobemidone Gavestinel Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Estimated glomerular filtration rate in non-diabetics ( 31451708) Migraine ( 22683712) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 28991256 25056061 29483656 23974872)
Interacting Genes		4 interacting genes: GRIN1 GRIN2D STAU1 TANC1	33 interacting genes: ABL1 CDH2 CIT CLTC CTNNB1 DLG2 DLG4 DLGAP4 DNM1 DUSP4 FUS GRIN1 HNRNPU HRAS HSPA1A IL16 INA MAP2 MAP2K2 NANOS1 NF1 PATJ PPP2R1A PPP2R2A PRKCB PRKCE PRKCG RAP2A RPS6KA3 SPTAN1 SYNGAP1 TJP1 TRAF3
Entrez ID		9118	2906
HPRD ID		05628	04095
Ensembl ID		ENSG00000148798	ENSG00000105464
Uniprot IDs		Q16352	O15399 Q59G17
PDB IDs
Enriched GO Terms of Interacting Partners?
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