LATS1 and PPP6R3

Data Source:
BioGRID (enzymatic study)

		LATS1	PPP6R3
Description		large tumor suppressor kinase 1	protein phosphatase 6 regulatory subunit 3
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Microtubule Organizing Center Cytosol Midbody	Golgi Membrane Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Estrogen Receptor Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Sister Chromatid Segregation Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Protein Phosphorylation Hormone-mediated Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Peptidyl-serine Phosphorylation Keratinocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Intracellular Estrogen Receptor Signaling Pathway Cellular Protein Localization Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Organ Growth Cytoplasmic Sequestering Of Protein Cell Division Mammary Gland Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Phosphoprotein Phosphatase Activity COPII Vesicle Coating
Pathways		Signaling by Hippo	Telomere Extension By Telomerase COPII-mediated vesicle transport
Drugs		Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Subcortical volume (MOSTest) ( 32665545) Testicular germ cell tumor ( 28604728)	Body size at age 10 ( 32376654) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860) Femoral neck section modulus ( 30888730) Fractures ( 30598549) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Monobrow ( 27182965) QT interval ( 29213071)
Interacting Genes		48 interacting genes: ALPP APP ARPC3 AURKB CAV1 CBY2 CDC26 CDK1 CEP76 EIF4EBP1 FOXL2 FSD2 GOLGA2 KRT31 LDOC1 LIMK1 LRRK2 MAGI3 MOAP1 MOB3A MOB3B MOB3C MOB4 NEDD4 NF2 NUAK1 NUAK2 OSTF1 PABPN1 PPM1F PPP1R11 PPP6R3 PTEN RAC1 SMURF1 SMURF2 SSX2IP STK3 STK4 TAZ TFIP11 TRAF1 UBE2I UBQLN2 WWOX WWP1 WWTR1 ZYX	5 interacting genes: LATS1 PRKDC TERF2IP TINF2 YWHAG
Entrez ID		9113	55291
HPRD ID		09147	10703
Ensembl ID		ENSG00000131023	ENSG00000110075
Uniprot IDs		O95835	A0A024R5F3 H7BXH2 Q5H9R7
PDB IDs		4ZRK 5B5W 5BRK
Enriched GO Terms of Interacting Partners?
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