USP8 and SEC31A

Data Source:
BioGRID (pull down)

		USP8	SEC31A
Description		ubiquitin specific peptidase 8	SEC31 homolog A, COPII coat complex component
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GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Postsynaptic Density Extrinsic Component Of Plasma Membrane Midbody Extrinsic Component Of Endosome Membrane Dendritic Spine Glutamatergic Synapse	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Vesicle Coat COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding SH3 Domain Binding Cadherin Binding	Structural Molecule Activity Protein Binding Calcium-dependent Protein Binding
	Biological Process	Mitotic Cytokinesis Ubiquitin-dependent Protein Catabolic Process Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Cellular Response To Nerve Growth Factor Stimulus	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II IRE1-mediated Unfolded Protein Response COPII Vesicle Coating Response To Calcium Ion COPII-coated Vesicle Cargo Loading
Pathways		Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity	COPII-mediated vesicle transport MHC class II antigen presentation XBP1(S) activates chaperone genes Antigen Presentation: Folding, assembly and peptide loading of class I MHC
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Diseases
GWAS		Ankylosing spondylitis ( 30946743) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494)	Adult asthma ( 27611488) Neutrophil percentage of white cells ( 27863252)
Interacting Genes		40 interacting genes: BACE1 BIRC6 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 EPS15 GRAP2 GRB2 H2AC20 H2BC21 KIF23 NBR1 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SRC STAM STAM2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ	14 interacting genes: APC ARIH1 FHL5 KLHL12 MYOM2 PDCD6 PEF1 PFDN1 PRNP REL SEC13 TNNT1 TSC22D2 USP8
Entrez ID		9101	22872
HPRD ID		04405	15314
Ensembl ID		ENSG00000138592	ENSG00000138674
Uniprot IDs		A0A024R5S4 A8K8N5 P40818	A0A024RDH6 A1LU61 O94979
PDB IDs		1WHB 2A9U 2GFO 2GWF 3N3K 6F09	3WXA
Enriched GO Terms of Interacting Partners?
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