DIRAS3 and PPM1D

Data Source:
BioGRID (two hybrid)

		DIRAS3	PPM1D
Description		DIRAS family GTPase 3	protein phosphatase, Mg2+/Mn2+ dependent 1D
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane	Nucleus Nucleoplasm Nucleolus Cytosol
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Gene Expression By Genetic Imprinting Small GTPase Mediated Signal Transduction	G2/M Transition Of Mitotic Cell Cycle DNA Methylation Chromatin Silencing Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic
Pathways			Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS			Blood urea nitrogen levels ( 31152163)
Interacting Genes		12 interacting genes: APC BAG4 BRMS1 CHEK2 FGFR4 KRAS MEOX2 PALB2 PPM1D PTPN1 TGFB1 WT1	24 interacting genes: BEX2 CASZ1 CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		9077	8493
HPRD ID		05547	05482
Ensembl ID		ENSG00000162595	ENSG00000170836
Uniprot IDs		O95661	A0A0S2Z4M2 O15297
PDB IDs		6NAZ
Enriched GO Terms of Interacting Partners?
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