CLDN12 and SEC13

Data Source:
BioGRID (two hybrid)

		CLDN12	SEC13
Description		claudin 12	SEC13 homolog, nuclear pore and COPII coat complex component
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Lateral Plasma Membrane	Golgi Membrane Kinetochore Nuclear Envelope Nucleoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat Nuclear Pore Outer Ring Intracellular Membrane-bounded Organelle Host Cell GATOR2 Complex Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Structural Molecule Activity Protein Binding Identical Protein Binding
	Biological Process	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Maintenance Of Blood-brain Barrier Tight Junction Assembly	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Protein Import Into Nucleus Intracellular Protein Transport Viral Process Viral Transcription Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of TOR Signaling Protein Exit From Endoplasmic Reticulum COPII Vesicle Coating Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus COPII-coated Vesicle Cargo Loading COPII-coated Vesicle Budding Regulation Of Cellular Response To Heat Positive Regulation Of TORC1 Signaling
Pathways		Tight junction interactions	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly COPII-mediated vesicle transport MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation Amino acids regulate mTORC1 EML4 and NUDC in mitotic spindle formation Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		4 interacting genes: ECHS1 SEC13 STRN4 TRARG1	13 interacting genes: ADGRF5 CFAP43 CLDN12 EGFR HAPLN2 HSPB1 LTB4R2 NUP98 RAB11A SEC16B SEC31A TRAF5 WDR44
Entrez ID		9069	6396
HPRD ID		13064	02538
Ensembl ID		ENSG00000157224	ENSG00000157020
Uniprot IDs		B2R687 P56749	A8MWR8 P55735
PDB IDs			3BG0 3BG1 5A9Q
Enriched GO Terms of Interacting Partners?
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