MACIR and MAPK7

Data Source:
BioGRID (two hybrid)

		MACIR	MAPK7
Description		macrophage immunometabolism regulator	mitogen-activated protein kinase 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Ciliary Transition Zone	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Inflammatory Response Negative Regulation Of Fibroblast Migration Protein Transport Negative Regulation Of Inflammatory Response Cilium Assembly Negative Regulation Of Cytokine Production Involved In Inflammatory Response	MAPK Cascade Cell Cycle Signal Transduction Axon Guidance Peptidyl-serine Phosphorylation CAMP-mediated Signaling Negative Regulation Of Heterotypic Cell-cell Adhesion Intracellular Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of Response To Cytokine Stimulus Cellular Response To Hydrogen Peroxide Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Transforming Growth Factor Beta Stimulus Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			ERK/MAPK targets ERK/MAPK targets Signalling to ERK5 Signalling to ERK5 ERKs are inactivated Senescence-Associated Secretory Phenotype (SASP) Gastrin-CREB signalling pathway via PKC and MAPK RET signaling
Drugs			Acetylsalicylic acid Minocycline Fostamatinib
Diseases
GWAS			Alzheimer's disease ( 30636644)
Interacting Genes		5 interacting genes: EXOSC8 MAPK7 MDFI PNMA1 TRAF1	30 interacting genes: ACTN4 APP CCDC6 EGLN3 ELK4 ETS1 FGF21 FOS GJA1 GOLGB1 GPSM3 MACIR MAP2K5 MEF2A MEF2C MEF2D MYC NFE2L2 NR1I2 PRKCZ PTPRR RAF1 RXRA SGK1 SH2D2A UBE2C YWHAB YWHAE ZBED6CL ZKSCAN1
Entrez ID		90355	5598
HPRD ID		12383	03952
Ensembl ID		ENSG00000181751	ENSG00000166484
Uniprot IDs		Q96GV9	A0A024QZ20 Q13164
PDB IDs			2Q8Y 4B99 4IC7 4IC8 4ZSG 4ZSJ 4ZSL 5BYY 5BYZ 5O7I 6HKM 6HKN
Enriched GO Terms of Interacting Partners?
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