UNC5A and NTN1

Data Source:
BioGRID (pull down)

		UNC5A	NTN1
Description		unc-5 netrin receptor A	netrin 1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane Neuron Projection Membrane Neuronal Cell Body Membrane Membrane Raft	Extracellular Region Basement Membrane Cytoplasm
	Molecular Function	Netrin Receptor Activity	Protein Binding
	Biological Process	Apoptotic Process Axon Guidance Neuron Projection Development Anterior/posterior Axon Guidance Netrin-activated Signaling Pathway	Neuron Migration Apoptotic Process Substrate-dependent Cell Migration, Cell Extension Nuclear Migration Ras Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Tissue Development Dendrite Development Regulation Of Cell Migration Negative Regulation Of Axon Extension Cdc42 Protein Signal Transduction Anterior/posterior Axon Guidance Inner Ear Morphogenesis Positive Regulation Of Axon Extension Regulation Of Synapse Assembly Mammary Gland Duct Morphogenesis Chemorepulsion Of Axon Cell-cell Adhesion Negative Regulation Of Netrin-activated Signaling Pathway Positive Regulation Of Cell Motility
Pathways		Netrin-1 signaling Netrin mediated repulsion signals Caspase activation via Dependence Receptors in the absence of ligand	Netrin-1 signaling Netrin-1 signaling DSCAM interactions DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Role of second messengers in netrin-1 signaling Regulation of commissural axon pathfinding by SLIT and ROBO
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Blood protein levels ( 30072576 29875488) Brain morphology (MOSTest) ( 32665545) Breast cancer (prognosis) ( 23319801) Cleft lip with or without cleft palate ( 28054174) Cortex volume ( 31530798) Feeling hurt ( 29500382) Heel bone mineral density ( 30598549 28869591) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Orofacial clefts ( 33137956 28054174) Percentage gas trapping ( 26030696) Rostral middle frontal gyrus volume ( 31530798) Total grey matter volume ( 31530798)
Interacting Genes		3 interacting genes: DAPK1 MAGED1 NTN1	5 interacting genes: ADORA2B DCC NEO1 UNC5A UNC5C
Entrez ID		90249	9423
HPRD ID		12131	03368
Ensembl ID		ENSG00000113763	ENSG00000065320
Uniprot IDs		H0Y8R2 Q6ZN44	O95631
PDB IDs		4V2A	4URT 6FKQ
Enriched GO Terms of Interacting Partners?
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