CCND2 and CALM2

Data Source:
BioGRID (pull down)

		CCND2	CALM2
Description		cyclin D2	calmodulin 2
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Membrane	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Plasma Membrane Sarcomere Vesicle Protein-containing Complex Calcium Channel Complex Catalytic Complex
	Molecular Function	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding	Calcium Ion Binding Protein Binding Adenylate Cyclase Binding Adenylate Cyclase Activator Activity Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Enzyme Regulator Activity Titin Binding N-terminal Myristoylation Domain Binding Protein Serine/threonine Kinase Activator Activity Ion Channel Binding Protein Phosphatase Activator Activity Disordered Domain Specific Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Heart Rate Detection Of Calcium Ion G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Substantia Nigra Development Positive Regulation Of Protein Autophosphorylation Regulation Of Cytokinesis Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Protein Dephosphorylation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Response To Calcium Ion Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation CaM pathway Platelet degranulation Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation DARPP-32 events Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT Calcineurin activates NFAT eNOS activation Transcriptional activation of mitochondrial biogenesis Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Smooth Muscle Contraction Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability VEGFR2 mediated cell proliferation Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Loss of phosphorylation of MECP2 at T308 Regulation of MECP2 expression and activity Ion transport by P-type ATPases Negative regulation of NMDA receptor-mediated neuronal transmission Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs Activation of AMPK downstream of NMDARs Long-term potentiation Long-term potentiation RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs			Chlorpromazine Cinchocaine Nicardipine Fluphenazine Isoflurane Trifluoperazine Loperamide Perphenazine Phenoxybenzamine Felodipine Melatonin Promethazine Pimozide Nifedipine Bepridil Calcium Aprindine Deacetoxyvinzolidine tert-butanol Trimethyllysine N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide Prenylamine Flunarizine (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Myristic acid Calcium citrate Calcium citrate Calcium citrate Calcium Phosphate Calcium Phosphate Calcium Phosphate Calcium levulinate Calcium phosphate dihydrate Calcium phosphate dihydrate Calcium phosphate dihydrate
Diseases		Testicular cancer
GWAS		Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) Blood glucose levels ( 31928498) Brown vs. black hair color ( 30531825) Colorectal cancer ( 30529582 26151821 24836286 31826910 23266556 23263487) Colorectal cancer or advanced adenoma ( 30510241) Glucocorticoid-induced osteonecrosis ( 26265699) Height ( 28552196 28270201) Low density lipoprotein cholesterol levels ( 32154731) Major depressive disorder ( 19107115 23377640) Mean corpuscular hemoglobin ( 28017375) Mean corpuscular volume ( 28017375) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 27841878 30578418) QT interval (drug interaction) ( 23459443) Red blood cell count ( 20139978 28017375) Red blood cell traits ( 23222517) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 32203549 32154731 31928498) Type 2 diabetes ( 22885922 30054458 29358691 30297969 31118516 32499647 28869590) Waist circumference ( 31928498)	Dialysis-related mortality ( 21546767)
Interacting Genes		64 interacting genes: ABCB5 ABL1 ADRB2 AKAP8 AKT1 ARAF ARNT AURKA BECN1 CALM1 CALM2 CALM3 CBLC CCNE1 CD44 CDK4 CDK5 CDK6 CDK7 CDKN1A CDKN1B CDKN2A CDKN2B CDKN2C DMTF1 EPHA2 ERBB2 FBXL2 FGFR4 FZR1 GLIS2 GRM1 H1-1 HGF HIF1A KAT2A KDELR2 LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MET NF2 NPDC1 PCGF2 PDGFRA PIK3CA PSMD10 PTEN RAF1 RASSF1 RB1 RELA RUNX1 SERTAD1 STK11 TEAD2 TERT TEX11 TNFRSF1A TSC1 TTYH2	52 interacting genes: ADAMTS12 ADCY8 AKAP9 ASCL2 C11orf65 CACNA1A CALD1 CAMTA2 CCND2 DDIT4L DLG1 EDF1 EGFR ESR1 ESR2 GRM5 GRM7 GSC2 INSR INVS IQCB1 IQCE IQCG IQCN IQGAP3 KCNIP3 KCNN1 KCNQ2 KCNQ3 KCNQ5 MARCKS MRPL20 MYF5 MYF6 MYO6 MYOD1 MYOG NEUROD1 NSMF PCNT POC5 PPEF1 PPEF2 RAB3B RPSA SDCBP SPATA17 STK11 TBC1D1 TCF4 USP6 ZNF280A
Entrez ID		894	805
HPRD ID		00451	00242
Ensembl ID		ENSG00000118971	ENSG00000143933
Uniprot IDs		P30279	B4DJ51 P0DP23 P0DP24 P0DP25 Q96HY3
PDB IDs		6EI2	1AJI 1CDL 1CLL 1CTR 1IWQ 1J7O 1J7P 1K90 1K93 1L7Z 1LVC 1NKF 1PK0 1S26 1SK6 1SW8 1UP5 1WRZ 1XFU 1XFV 1XFW 1XFX 1XFY 1XFZ 1Y6W 1YR5 1YRT 1YRU 1ZOT 1ZUZ 2BE6 2F3Y 2F3Z 2HF5 2I08 2JZI 2K0E 2K0F 2K0J 2K61 2KNE 2KUG 2KUH 2L53 2L7L 2LGF 2LL6 2LL7 2LQC 2LQP 2LV6 2M0J 2M0K 2M55 2MG5 2N27 2N6A 2N77 2N8J 2R28 2V01 2V02 2VAY 2W73 2WEL 2X0G 2Y4V 3BYA 3DVE 3DVJ 3DVK 3DVM 3EWT 3EWV 3G43 3HR4 3J41 3O77 3O78 3OXQ 3SUI 3UCT 3UCW 3UCY 4BW7 4BW8 4BYF 4DCK 4DJC 4GOW 4JPZ 4JQ0 4L79 4LZX 4M1L 4OVN 4Q57 4Q5U 4UMO 4UPU 4V0C 5COC 5DBR 5DOW 5DSU 5GGM 5I0I 5J03 5J8H 5JQA 5JTH 5K7L 5K8Q 5NIN 5OEO 5TP5 5TP6 5V02 5V03 5V7X 5VMS 5WBX 5WC5 5WSU 5WSV 6B8L 6B8M 6B8N 6B8P 6B8Q 6BUT 6C1D 6C1G 6C1H 6CNM 6CNN 6CNO 6DAD 6DAE 6DAF 6DAH 6E2F 6E2G 6EEB 6FEG 6FEH 6GDK 6GDL 6HCS 6HR1 6JI8 6JII 6JIU 6JIY 6JRS 6JV2 6K4K 6K4L 6K4R 6K67 6M2W 6M7H 6MUD 6MUE 6N5W 6O5G 6OS4 6PAW 6PBX 6PBY 6PLM 6S5T 6SZ5 6U39 6U3A 6U3B 6U3D 6UZZ 6V00 6V01 6Y4O 6Y4P 6Y94 6Y95 7CR3 7CR4 7CR7
Enriched GO Terms of Interacting Partners?
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