FOXH1 and SERGEF

Data Source:
BioGRID (two hybrid)

		FOXH1	SERGEF
Description		forkhead box H1	secretion regulating guanine nucleotide exchange factor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Activin Responsive Factor Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding SMAD Binding Androgen Receptor Binding Co-SMAD Binding R-SMAD Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Heart Looping Secondary Heart Field Specification Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Embryonic Heart Tube Anterior/posterior Pattern Specification Aorta Morphogenesis Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Axial Mesoderm Development Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry	Signal Transduction Negative Regulation Of Protein Secretion Regulation Of Catalytic Activity
Pathways		Signaling by NODAL Signaling by Activin
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656) Educational attainment ( 25201988) General cognitive ability ( 29844566)	Alcohol consumption (drinks per week) ( 30643258) Body mass index ( 26426971)
Interacting Genes		67 interacting genes: AOC1 ARID5A ATP23 ATXN1L BATF2 C10orf55 C11orf1 C19orf54 CEACAM6 CRX CRYBA1 CYSRT1 DAZAP2 DRAP1 FAM168B FAM83A FOXD2 FOXG1 HDHD3 HEY1 HLX HOXA1 HSF4 KLHL26 KRTAP11-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP3-1 KRTAP3-3 KRTAP7-1 LASP1 MAGED1 MGAT5B MSX2 NKX2-5 NOTO OXER1 PLA2G10 PNMA5 PPP1R37 PRR20A PRR20B PRR20C PRR20D PRR20E PRR22 RBM46 RBPMS2 RNF144B SERGEF SMAD2 SMAD3 SMAD4 SOX14 SOX4 TEKT5 TFG TLX3 TSC1 UBAP2 UFSP1 ZC3H10 ZIC1 ZNF34 ZNF503	8 interacting genes: DPH3 EXOC2 FOXH1 HGS KDM1A PITX1 PRMT6 SPAG8
Entrez ID		8928	26297
HPRD ID		04689	06926
Ensembl ID		ENSG00000160973	ENSG00000129158
Uniprot IDs		O75593	A8K8C1 Q9UGK8
PDB IDs		5XOC
Enriched GO Terms of Interacting Partners?
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