PABPC4 and HAP1

Data Source:
HPRD (two hybrid)

		PABPC4	HAP1
Description		poly(A) binding protein cytoplasmic 4	huntingtin associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex	Nucleolus Mitochondrion Lysosome Early Endosome Autophagosome Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Dendrite Growth Cone Cytoplasmic Vesicle Dendritic Spine Axon Cytoplasm
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding Poly(C) RNA Binding	Signaling Receptor Binding Protein Binding Myosin Binding Ion Channel Binding Brain-derived Neurotrophic Factor Binding
	Biological Process	RNA Processing RNA Catabolic Process Translation Blood Coagulation Regulation Of MRNA Stability Myeloid Cell Development	Protein Targeting Exocytosis Autophagy Chemical Synaptic Transmission Brain Development Anterograde Axonal Transport Retrograde Axonal Transport Protein Localization Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Neurogenesis Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Positive Regulation Of Neurogenesis Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Amyloid-beta Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly
Pathways
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronic obstructive pulmonary disease ( 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Coffee consumption ( 31046077) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 27618448) HDL cholesterol ( 24097068 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) High density lipoprotein cholesterol levels ( 29615537) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Red cell distribution width ( 32888494 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Triglyceride levels ( 32203549) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Developmental language disorder (syntactic complexity) ( 27016271) Esophageal cancer (squamous cell) ( 22960999)
Interacting Genes		15 interacting genes: CDC42 DUX4 EEF1A1 GDF9 HAP1 IL7R MED31 PHLDA1 RIF1 SETDB1 SMAD9 SREK1 SRPK2 UBC XRN1	93 interacting genes: AEN ANTKMT APLP1 ATP5MF BARD1 BRD7 C1orf216 C2CD6 C7orf25 C8orf33 CBX8 CCDC113 CCDC13 CDC73 CDK18 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM50B FEZ1 GABARAPL2 GADD45G GIT1 GPRASP2 HDAC4 HGS HMOX2 HOXB5 HSPA1A HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 MSGN1 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A NOD2 NOP53 PABPC4 PCM1 PDCD7 PFDN1 PKN1 PPID PPOX PPP1R18 PRPF31 PSMD11 RER1 RHPN1 RIF1 RPS10 RPS25 SCNM1 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZFP1 ZMAT2 ZNF124 ZNF20 ZNF24 ZNF33B ZNF490 ZNF572 ZNF575 ZNF648 ZNF691 ZNF835
Entrez ID		8761	9001
HPRD ID		04557	02972
Ensembl ID		ENSG00000090621	ENSG00000173805
Uniprot IDs		Q13310	P54257
PDB IDs
Enriched GO Terms of Interacting Partners?
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