TNFSF13 and SDC2

Data Source:
HPRD (in vivo)

		TNFSF13	SDC2
Description		TNF superfamily member 13	syndecan 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Integral Component Of Membrane Lysosomal Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding Receptor Ligand Activity	Protein Binding PDZ Domain Binding Identical Protein Binding
	Biological Process	Immune Response Signal Transduction Positive Regulation Of Cell Population Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of MRNA Stability Positive Regulation Of Isotype Switching To IgA Isotypes	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Biological_process Cell Migration Post-translational Protein Modification Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Dendrite Morphogenesis Regulation Of Dendrite Morphogenesis Leukocyte Migration
Pathways		HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPHB-mediated forward signaling Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation Retinoid metabolism and transport
Drugs			Sargramostim
Diseases
GWAS		Albumin-globulin ratio ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) IgA levels ( 22864923 28628107) IgA nephropathy ( 26028593 25305756 22197929) IgM levels ( 23118916) Myopia ( 27182965) Non-albumin protein levels ( 22558069 29403010) Serum total protein level ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Post-traumatic stress disorder ( 26114229) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 SGTB TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B	28 interacting genes: ANOS1 ASPH BAG6 CASK CSF2 CYP2C18 EPHB2 EZR FGF2 FN1 HGF ITGB4 LAMA3 NF1 PF4 PPP3CC PRKCA PRKCB PRKCG REG3A SDCBP SERPINA1 SERPINC1 SPARC TGFB1 TGFBR3 TNFSF13 TRAPPC4
Entrez ID		8741	6383
HPRD ID		05128	00803
Ensembl ID		ENSG00000161955	ENSG00000169439
Uniprot IDs		B3KR02 O75888 Q2QBA2	A0A024R9D1 E9PBI9 P34741
PDB IDs		4ZCH	6ITH
Enriched GO Terms of Interacting Partners?
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