MYOM1 and SYNE1

Data Source:
BioGRID (two hybrid)

		MYOM1	SYNE1
Description		myomesin 1	spectrin repeat containing nuclear envelope protein 1
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GO Annotations	Cellular Component	Striated Muscle Myosin Thick Filament M Band	P-body Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytoskeleton Integral Component Of Membrane Sarcomere Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Postsynaptic Membrane
	Molecular Function	Protein Binding Structural Constituent Of Muscle Kinase Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding	RNA Binding Actin Binding Protein Binding Lamin Binding Enzyme Binding Protein Homodimerization Activity Actin Filament Binding Cytoskeleton-nuclear Membrane Anchor Activity
	Biological Process	Extraocular Skeletal Muscle Development Muscle Contraction Positive Regulation Of Gene Expression Protein Kinase A Signaling Positive Regulation Of Protein Secretion	Nucleus Organization Golgi Organization Spermatogenesis Muscle Cell Differentiation Nuclear Matrix Anchoring At Nuclear Membrane
Pathways			Meiotic synapsis
Drugs
Diseases			Emery-Dreifuss muscular dystrophy Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Brain volume in infants (white matter) ( 28763065) Night sleep phenotypes ( 27126917) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 28115744 21926972 31043756 28072414 20351715 21738484) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Body mass index ( 26426971) Endometriosis ( 28537267) Heel bone mineral density ( 30598549 28869591) Post bronchodilator FEV1 ( 26634245) Tonometry ( 17903302) Uterine fibroids ( 31249589 30194396 31649266)
Interacting Genes		16 interacting genes: ANKRD28 C1QTNF9 CLK1 DNAJB6 DYSF KRT31 KRTAP1-1 KRTAP5-7 MTUS2 MYH9 PDE4DIP PPP1R16A SYNE1 TFIP11 TRIM23 TTN	21 interacting genes: ACTC1 APC BDKRB2 CAPN1 CDC42 CDC5L CEP63 DISC1 DTNBP1 ECPAS EMD LINC00839 LMNA MTDH MUSK MYOM1 NDEL1 SH3BP5 TNIK TP53RK USP21
Entrez ID		8736	23345
HPRD ID		04618	09762
Ensembl ID		ENSG00000101605	ENSG00000131018
Uniprot IDs		P52179	A0A0C4DG40 B4E3R1 B7Z9Y6 F8WAI0 Q8NF91
PDB IDs		2R15 2Y23 2Y25 3RBS 5FM4 5FM5 5FM8	4DXR 6R15
Enriched GO Terms of Interacting Partners?
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