GPAA1 and GRIK5

Data Source:
HPRD (two hybrid)

		GPAA1	GRIK5
Description		glycosylphosphatidylinositol anchor attachment 1	glutamate ionotropic receptor kainate type subunit 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Membrane GPI-anchor Transamidase Complex	Nucleoplasm Endoplasmic Reticulum Plasma Membrane Dendrite Kainate Selective Glutamate Receptor Complex Terminal Bouton Perikaryon Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding Tubulin Binding GPI Anchor Binding	Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity SH3 Domain Binding PDZ Domain Binding Signaling Receptor Activity Identical Protein Binding Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Proteolysis Protein Retention In ER Lumen Attachment Of GPI Anchor To Protein Protein-containing Complex Assembly	Protein Retention In ER Lumen Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Positive Regulation Of Neuron Apoptotic Process Modulation Of Chemical Synaptic Transmission Establishment Of Localization In Cell Excitatory Postsynaptic Potential Cellular Response To Glucose Stimulus
Pathways		Attachment of GPI anchor to uPAR	Activation of Ca-permeable Kainate Receptor
Drugs			Glutamic acid Butabarbital Topiramate
Diseases
GWAS		Asthma ( 31959851) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Serum metabolite levels ( 23093944)	Bipolar disorder ( 21771265) Lymphocyte counts ( 32888494) Meat-related diet ( 32066663) Monocyte count ( 32888494)
Interacting Genes		10 interacting genes: AGTR1 AQP2 EIF3E GNRHR GRIK5 PIGK PIGT PIGU PIN1 PRR13	8 interacting genes: DLG4 GOLM1 GPAA1 GRID2 GRIK2 GRIK3 LRSAM1 MLF1
Entrez ID		8733	2901
HPRD ID		04334	02614
Ensembl ID		ENSG00000197858	ENSG00000105737
Uniprot IDs		O43292	Q16478
PDB IDs
Enriched GO Terms of Interacting Partners?
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