PAGE1 and TFRC

Data Source:
BioGRID (two hybrid)

		PAGE1	TFRC
Description		PAGE family member 1	transferrin receptor
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Endosome Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Cell Surface Endosome Membrane Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle Extracellular Vesicle HFE-transferrin Receptor Complex
	Molecular Function	Protein Binding	Virus Receptor Activity RNA Binding Double-stranded RNA Binding Transferrin Receptor Activity Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding
	Biological Process		Regulation Of Cell Growth Positive Regulation Of Protein Phosphorylation Iron Ion Transport Cellular Iron Ion Homeostasis Positive Regulation Of Gene Expression Negative Regulation Of Mitochondrial Fusion Osteoclast Differentiation Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein-containing Complex Assembly Receptor Internalization Positive Regulation Of Peptidyl-serine Phosphorylation Transferrin Transport Intracellular Signal Transduction Cellular Response To Drug Positive Regulation Of T Cell Proliferation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Bone Resorption Positive Regulation Of Isotype Switching Viral Entry Into Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Membrane Organization Transport Across Blood-brain Barrier Positive Regulation Of Protein Localization To Nucleus Cellular Response To Leukemia Inhibitory Factor
Pathways			Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Transferrin endocytosis and recycling
Drugs			Iron Ferrous sulfate anhydrous Ferric cation Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Tetraferric tricitrate decahydrate Ferric derisomaltose
Diseases
GWAS			Asthma ( 31959851 30929738) Asthma (adult onset) ( 30929738) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 25352340) Mean corpuscular hemoglobin ( 32888494 28453575 20139978 27863252 19862010) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 28453575 20139978 27863252 19862010) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neurofibrillary tangles ( 31497858) Pancreatic cancer ( 22158540) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 32499647)
Interacting Genes		12 interacting genes: CMTM7 DDX49 FAM9B MGST3 PLPP4 SLC1A1 SLC2A5 TFRC TMEM14B TMEM254 TMEM60 TNF	31 interacting genes: ACAP1 AQP6 ARL13B ASGR2 B4GALT1 C1orf159 CD247 CD4 CREB3L1 FAM209A FAM210B GABARAP GET1 GPR152 HFE HIBADH LHFPL5 LMNA MFF MGST3 PAGE1 RAB5B RAB8A RANBP9 RASSF3 RELL2 RMDN3 SGTA SLC10A1 SLC18A1 TF
Entrez ID		8712	7037
HPRD ID		02240	01812
Ensembl ID		ENSG00000068985	ENSG00000072274
Uniprot IDs		O75459	A8K6Q8 B7Z2I6 G3V0E5 P02786 Q7Z3E0
PDB IDs			1CX8 1DE4 1SUV 2NSU 3KAS 3S9L 3S9M 3S9N 6D03 6D04 6D05 6GSR 6H5I 6OKD 6W3H 6Y76
Enriched GO Terms of Interacting Partners?
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