SERPINH1 and H1-5

Data Source:
BioGRID (pull down)

		SERPINH1	H1-5
Description		serpin family H member 1	H1.5 linker histone, cluster member
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Raft Collagen-containing Extracellular Matrix	Chromatin Nucleosome Heterochromatin Nucleus
	Molecular Function	RNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Collagen Binding Unfolded Protein Binding	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding Histone Deacetylase Binding
	Biological Process	Chondrocyte Development Involved In Endochondral Bone Morphogenesis Response To Unfolded Protein Negative Regulation Of Endopeptidase Activity Collagen Fibril Organization Collagen Biosynthetic Process Protein Maturation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Positive Regulation Of Cell Growth Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Protein Stabilization Positive Regulation Of Histone H3-K9 Methylation Establishment Of Protein Localization To Chromatin
Pathways		Collagen biosynthesis and modifying enzymes	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Height ( 28552196 20881960 22021425 25282103 25429064 31562340 28270201) Hip circumference adjusted for BMI ( 25673412) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		18 interacting genes: BAG6 BRCA2 C1QL3 CD9 CDK9 CEP70 COL26A1 ESR2 FEZ1 H1-5 KLF13 LINC01554 NSG2 PPARG SLC2A4 SLC35F6 UBQLN4 UBTF	31 interacting genes: CBX5 CCNA1 CCNA2 CCNB1 CCNE1 CDC42 CDK1 CDK2 CDK5 CDKN1A CDKN1B EHMT2 HPF1 IRAK4 KAT2A KAT2B L3MBTL1 LOX MELK MLLT1 NSD1 PARP1 PARP2 PRKCA PRKCB PRKCD PRKCZ RIPK3 RPS6KA5 SERPINH1 SIRT1
Entrez ID		871	3009
HPRD ID		02968	00821
Ensembl ID		ENSG00000149257	ENSG00000184357
Uniprot IDs		A0A024R5K8 A8K259 P50454	P16401
PDB IDs			2FE2 2RHI
Enriched GO Terms of Interacting Partners?
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