SLC4A4 and CA4

Data Source:
HPRD (in vitro, in vivo)

		SLC4A4	CA4
Description		solute carrier family 4 member 4	carbonic anhydrase 4
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Spanning Component Of Plasma Membrane Extracellular Exosome	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Inorganic Anion Exchanger Activity Protein Binding Sodium:bicarbonate Symporter Activity Symporter Activity Transmembrane Transporter Activity Identical Protein Binding	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding Hydro-lyase Activity
	Biological Process	Sodium Ion Transport Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Positive Regulation Of Glycolytic Process Ion Homeostasis Regulation Of Intracellular PH Transmembrane Transport Anion Transmembrane Transport Transport Across Blood-brain Barrier	One-carbon Metabolic Process Bicarbonate Transport
Pathways		Bicarbonate transporters Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide
Drugs			Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Zonisamide Trichlormethiazide Diclofenamide Brinzolamide Ellagic acid Sodium carbonate
Diseases		Proximal renal tubular acidosis (RTA type 2)	Retinitis pigmentosa (RP)
GWAS		Age-related nuclear cataracts ( 24951543) Diastolic blood pressure ( 30578418) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549 28869591) Mosquito bite size ( 28199695) QT interval ( 24952745 29874175) Refractive error ( 32231278)
Interacting Genes		5 interacting genes: CA2 CA4 PRKACA SLC4A7 SREBF2	5 interacting genes: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4
Entrez ID		8671	762
HPRD ID		04516	00261
Ensembl ID		ENSG00000080493	ENSG00000167434
Uniprot IDs		A5JJ20 Q9Y6R1	P22748
PDB IDs		6CAA	1ZNC 3F7B 3F7U 3FW3 5IPZ 5JN8 5JN9 5JNA 5JNC 5KU6
Enriched GO Terms of Interacting Partners?
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