SOCS1 and IGF1R

Data Source:
HPRD (two hybrid, in vivo)

		SOCS1	IGF1R
Description		suppressor of cytokine signaling 1	insulin like growth factor 1 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex Cytoplasmic Vesicle Cytoplasmic Ribonucleoprotein Granule	Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Membrane Axon Alphav-beta3 Integrin-IGF-1-IGF1R Complex Intracellular Membrane-bounded Organelle Receptor Complex Protein Kinase Complex
	Molecular Function	Protein Kinase Inhibitor Activity Insulin-like Growth Factor Receptor Binding Protein Binding Kinase Inhibitor Activity Protein Kinase Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor-activated Receptor Activity Insulin Receptor Binding Protein Binding Insulin-like Growth Factor Binding ATP Binding Insulin-like Growth Factor I Binding Identical Protein Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein Transporter Activity
	Biological Process	Regulation Of Cytokine Production Regulation Of Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Receptor Signaling Pathway Via JAK-STAT Regulation Of Activation Of Janus Kinase Activity Protein Ubiquitination Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Phosphatidylinositol 3-kinase Activity Fat Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Regulation Of Interferon-gamma-mediated Signaling Pathway Cellular Response To Amino Acid Stimulus	Immune Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Positive Regulation Of Cell Migration Positive Regulation Of Kinase Activity Peptidyl-tyrosine Autophosphorylation Glucose Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MAPK Cascade Transcytosis Regulation Of JNK Cascade Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Inactivation Of MAPKK Activity Positive Regulation Of Protein Kinase B Signaling Cellular Response To Glucose Stimulus Dendritic Spine Maintenance Amyloid-beta Clearance Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Amyloid-beta
Pathways		Interleukin-7 signaling Regulation of KIT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events triggered by IGF1R SHC-related events triggered by IGF1R Extra-nuclear estrogen signaling
Drugs			Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Phosphoaminophosphonic Acid-Adenylate Ester ATL1101 XL228 rhIGFBP-3 Linsitinib Teprotumumab (4Z)-6-bromo-4-({[4-(pyrrolidin-1-ylmethyl)phenyl]amino}methylidene)isoquinoline-1,3(2H,4H)-dione 3-[5-(1H-IMIDAZOL-1-YL)-7-METHYL-1H-BENZIMIDAZOL-2-YL]-4-[(PYRIDIN-2-YLMETHYL)AMINO]PYRIDIN-2(1H)-ONE Somatrem Insulin degludec Cixutumumab Brigatinib Mecasermin rinfabate
Diseases			Malignant pleural mesothelioma Synovial sarcoma
GWAS		Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 31959851 29273806) Bulimia nervosa ( 23568457) Celiac disease ( 20190752) Crohn's disease ( 28067908) Crohn's disease and psoriasis ( 22482804) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 27399966 26502338)	Adult body size ( 32376654) Arthritis (juvenile idiopathic) ( 22354554) Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758 27680694) Blood urea nitrogen levels ( 31152163 29403010) Creatinine levels ( 29124443 29403010) Dental caries (decayed and filled deciduous teeth) ( 31533690) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometriosis ( 27506219) Estimated glomerular filtration rate ( 31152163 31015462 29124443 30604766) Fasting plasma glucose ( 25187374) Global electrical heterogeneity phenotypes ( 29622589) Glomerular filtration rate ( 29403010) Height ( 28552196 20881960 25429064 31562340) Hemoglobin ( 32888494) Hyperuricemia ( 29124443) Offspring birth weight ( 31043758) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) QRS duration ( 30012220) Red cell distribution width ( 32888494) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Rosacea symptom severity ( 29771307) Serum uric acid levels ( 30993211 29124443 29403010) Smoking status (ever vs never smokers) ( 30643258) Thyroid volume in Hashimotoâ€™s thyroiditis ( 32019955) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Type 2 diabetes ( 32499647) Urate levels ( 31985003 31578528 23263486) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		47 interacting genes: AXL COMMD1 CRK CSF1 CSF1R CUEDC2 CXCR4 CYTIP EGFR ELOB ELOC ERBB2 ERBB4 FLT3 FYN GHR GRB2 IFNAR1 IFNGR1 IGF1R IL2RB INSR IRF7 IRS1 IRS2 ITK JAK1 JAK2 JAK3 KIT MET MPL NCK1 PDGFRB PIK3R1 PIK3R2 PIM2 PTK2 RELA SH3GL1 TEC TEK TIRAP TRIM8 TYK2 VAV1 VAV2	95 interacting genes: AMY2A APP ARHGEF12 BAP1 CAV1 CBL CDK4 CDKN2B CRK CRKL CSK CYP17A1 DOK4 DOK5 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 EEA1 EHD1 ERBB2 ESR1 FFAR2 FGFR4 GIPC1 GNAI1 GNAI2 GRB10 GRB14 GRM1 HOXC6 IGF1 IGF2 IGFBP3 IL13RA2 ILKAP INS INSR IRS1 IRS2 IRS4 ITGB1 JAK1 JAK2 KCNIP3 KDELR2 KL KLK5 KRT27 LYPD3 MAP3K5 MDM2 MTA3 NAT2 NEDD4 NF2 PCNA PIK3R1 PIK3R2 PIK3R3 PPM1A PRKCD PRKD1 PTPN1 PTPN11 PTPN12 PTPN6 PTPN7 PTPRR RACK1 RASA1 RELA RPL11 SH2B1 SHC1 SIRPA SOCS1 SOCS2 SOCS3 SRC STAT3 STYX THRSP TTYH2 UBC VAV3 VPS45 YWHAB YWHAE YWHAG YWHAZ
Entrez ID		8651	3480
HPRD ID		04669	00932
Ensembl ID		ENSG00000185338	ENSG00000140443
Uniprot IDs		O15524 Q4JHT5	C9J5X1 P08069
PDB IDs			1IGR 1JQH 1K3A 1M7N 1P4O 2OJ9 2ZM3 3D94 3F5P 3I81 3LVP 3LW0 3NW5 3NW6 3NW7 3O23 3QQU 4D2R 4XSS 5FXQ 5FXR 5FXS 5HZN 5U8Q 5U8R 6JK8 6VWG 6VWH 6VWI 6VWJ
Enriched GO Terms of Interacting Partners?
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