CBFB and CHGB

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CBFB	CHGB
Description		core-binding factor subunit beta	chromogranin B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Membrane Core-binding Factor Complex	Extracellular Space Endoplasmic Reticulum Lumen Secretory Granule
	Molecular Function	Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding	Hormone Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Osteoblast Differentiation Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lymphocyte Differentiation Myeloid Cell Differentiation Regulation Of Wnt Signaling Pathway Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation Regulation Of Keratinocyte Differentiation Regulation Of Myeloid Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of B Cell Receptor Signaling Pathway Definitive Hemopoiesis Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Bicellular Tight Junction Assembly	Signal Transduction Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity RUNX2 regulates osteoblast differentiation RUNX2 regulates osteoblast differentiation RUNX2 regulates chondrocyte maturation RUNX2 regulates bone development RUNX2 regulates genes involved in cell migration RUNX2 regulates genes involved in cell migration RUNX2 regulates genes involved in differentiation of myeloid cells Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252)	Metabolite levels ( 23823483) Uterine fibroid number (single vs multiple) ( 30196971)
Interacting Genes		9 interacting genes: CBFA2T2 CHGB CHRM5 COPRS RAB2A RNF7 RUNX1 RUNX2 RUNX3	34 interacting genes: ACACA ANXA7 APP ATXN2 CBFB CCDC92 CDKN1A FGFR3 LRRK1 LRRK2 MARK3 MFHAS1 MGLL MOGS OGG1 PKN2 POLD1 POLR2E PRAG1 PTEN RAC2 RAP1B RCC1 RXRG S100A8 SAFB2 SLC25A6 TAZ TK1 TUBB2A TWF2 UBQLN1 UBTF YLPM1
Entrez ID		865	1114
HPRD ID		00418	07512
Ensembl ID		ENSG00000067955	ENSG00000089199
Uniprot IDs		A0A024R6X2 Q13951	P05060
PDB IDs		1CL3 1E50 1H9D 4N9F 6NIL 6P59
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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