RFXANK and CIITA

Data Source:
HPRD (in vitro, in vivo)

		RFXANK	CIITA
Description		regulatory factor X associated ankyrin containing protein	class II major histocompatibility complex transactivator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Intercellular Bridge RNA Polymerase II Transcription Regulator Complex	Nucleoplasm Cytosol PML Body
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Histone Deacetylase Binding	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Transcription Coactivator Activity Protein Binding ATP Binding GTP Binding Protein C-terminus Binding Transferase Activity, Transferring Acyl Groups Activating Transcription Factor Binding Protein-containing Complex Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Ras Protein Signal Transduction Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Inflammatory Response Immune Response Negative Regulation Of Collagen Biosynthetic Process Response To Interferon-gamma Positive Regulation Of MHC Class I Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Viral Entry Into Host Cell Response To Antibiotic Interferon-gamma-mediated Signaling Pathway
Pathways			Interferon gamma signaling
Drugs
Diseases		Bare lymphocyte syndrome (BLS) type2 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency	Bare lymphocyte syndrome (BLS) type2 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Refractive error ( 32231278)	Alopecia areata ( 25608926) Asthma ( 31619474) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Celiac disease ( 22057235 20190752) Monocyte percentage of white cells ( 32888494) Nasopharyngeal carcinoma ( 27436580) Systemic lupus erythematosus ( 27399966 26502338) Ulcerative colitis ( 20228799)
Interacting Genes		6 interacting genes: CIITA HDAC4 HDAC5 RAF1 RFX5 RFXAP	17 interacting genes: CDK1 GSK3B GTF2B HDAC1 HDAC4 HDAC5 KAT2B NCOA1 NFYB PRKACA RFX5 RFXANK SMARCA4 TAF6 TAF9 XPO1 ZXDC
Entrez ID		8625	4261
HPRD ID		04435	02475
Ensembl ID		ENSG00000064490	ENSG00000179583
Uniprot IDs		A0A024R7M1 A0A024R7P0 O14593	A0A087X2I7 A0A0B4J1S1 P33076 Q66X48
PDB IDs		3UXG 3V30 6MEW
Enriched GO Terms of Interacting Partners?
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