RUNX2 and ALYREF

Data Source:
BioGRID (pull down)

		RUNX2	ALYREF
Description		RUNX family transcription factor 2	Aly/REF export factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol	Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding ATP Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Protein Binding C5-methylcytidine-containing RNA Binding
	Biological Process	Ossification Osteoblast Differentiation Chondrocyte Differentiation Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Hemopoiesis Neuron Differentiation BMP Signaling Pathway Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Regulation Of DNA Recombination MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Export From Nucleus MRNA Export From Nucleus Viral Process MRNA 3'-end Processing Replication Fork Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus
Pathways			Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases		Cleidocranial dysplasia
GWAS		Brain morphology (MOSTest) ( 32665545) Central corneal thickness ( 32528159 29760442) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) facial morphology traits (multivariate analysis) ( 27193062) Gout (normal type) ( 32238385) Height ( 25429064 18391951) Hip minimal joint space width ( 27701424) Hip shape (DXA scan) ( 30320955) Intraocular pressure ( 29785010 30054594) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lymphocyte percentage of white cells ( 32888494) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Periodontal microbiota ( 22699663) Progressive supranuclear palsy ( 30089514) Subcortical volume (MOSTest) ( 32665545) Survival in pancreatic cancer ( 28470677) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		37 interacting genes: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HDAC7 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF XRCC5 XRCC6 YAP1	11 interacting genes: AKT1 DDX39B ESR1 IL7R LEF1 MAGOH NXF1 PTEN RUNX2 THOC6 UPF3A
Entrez ID		860	10189
HPRD ID		02566	09168
Ensembl ID		ENSG00000124813	ENSG00000183684
Uniprot IDs		A0A0D9SEN7 Q13950 Q32MY8	E9PB61 Q86V81
PDB IDs			3ULH
Enriched GO Terms of Interacting Partners?
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