HAT1 and ACAA1

Data Source:
BioGRID (enzymatic study)

		HAT1	ACAA1
Description		histone acetyltransferase 1	acetyl-CoA acyltransferase 1
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Protein-containing Complex	Extracellular Region Peroxisome Peroxisomal Matrix Cytosol Membrane Specific Granule Lumen
	Molecular Function	Histone Acetyltransferase Activity Protein Binding H4 Histone Acetyltransferase Activity Histone Binding	Acetyl-CoA C-acetyltransferase Activity Acetyl-CoA C-acyltransferase Activity Protein Binding Acetate CoA-transferase Activity Palmitoyl-CoA Oxidase Activity Acetyl-CoA C-myristoyltransferase Activity
	Biological Process	DNA Packaging DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Chromatin Silencing At Telomere Internal Protein Amino Acid Acetylation Response To Nutrient Histone H4 Acetylation	Very Long-chain Fatty Acid Metabolic Process Protein Targeting To Peroxisome Fatty Acid Beta-oxidation Bile Acid Metabolic Process Phenylacetate Catabolic Process Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Neutrophil Degranulation
Pathways		HATs acetylate histones	alpha-linolenic acid (ALA) metabolism Beta-oxidation of very long chain fatty acids Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import TYSND1 cleaves peroxisomal proteins
Drugs			Trimetazidine
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Myopia ( 27182965) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Gut microbiota (bacterial taxa) ( 27723756)
Interacting Genes		23 interacting genes: ACAA1 H2AC20 H3-4 H3C1 H4-16 H4C1 H4C14 HTR2B KANK4 MEOX2 MORN5 PRKAA2 RBBP4 REL SMAD7 SNAPC1 STEEP1 TCF4 TEPSIN TNFAIP1 TRIB3 YWHAQ ZSCAN4	4 interacting genes: FEM1A HAT1 TFCP2 TXNDC11
Entrez ID		8520	30
HPRD ID		04339	06815
Ensembl ID		ENSG00000128708	ENSG00000060971
Uniprot IDs		O14929	A0A024R2M6 A0A140VJX0 P09110
PDB IDs		2P0W 6VO5	2IIK
Enriched GO Terms of Interacting Partners?
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