IKBKG and MAP3K7

Data Source:
BioGRID (pull down, affinity chromatography technology)

		IKBKG	MAP3K7
Description		inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	mitogen-activated protein kinase kinase kinase 7
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol IkappaB Kinase Complex Protein-containing Complex Mitotic Spindle	Nucleus Ada2/Gcn5/Ada3 Transcription Activator Complex Cytosol Plasma Membrane IkappaB Kinase Complex Endosome Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Metal Ion Binding Protein Heterodimerization Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Linear Polyubiquitin Binding Transferrin Receptor Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Receptor Tyrosine Kinase Binding Identical Protein Binding Scaffold Protein Binding
	Biological Process	Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-independent Toll-like Receptor Signaling Pathway Apoptotic Process Inflammatory Response Immune Response Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Response To Virus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Positive Regulation Of Macroautophagy Protein Deubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Anoikis Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Establishment Of Vesicle Localization Protein-containing Complex Assembly Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Negative Regulation Of Neuron Death	Activation Of MAPKK Activity Activation Of MAPK Activity Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation JNK Cascade Viral Process Positive Regulation Of Macroautophagy Protein Deubiquitination Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Anoikis Positive Regulation Of JUN Kinase Activity Histone H3 Acetylation T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 SUMOylation of immune response proteins Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ub-specific processing proteases Ovarian tumor domain proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Activation of NF-kappaB in B cells NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation Ca2+ pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs		AGRO100 Tarenflurbil
Diseases		Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect Incontinentia pigmenti Osteoporosis, lymphedema, anhydrotic ectodermal dysplasia with immunodeficiency (OLEDAID); Ectodermal dysplasia, anhidrotic, with immunodeficiency, osteopetrosis, and lymphedema
GWAS		Hemoglobin levels ( 26366553)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bone mineral density (hip) ( 30172743) Celiac disease ( 20190752) Graves' disease ( 21841780) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		242 interacting genes: ABCA1 ACBD6 ADAP2 AIP ALK AMMECR1L APRT ARF4 ARF5 ARF6 ARGLU1 ARHGDIA ARL6IP4 ARPP19 AVPI1 BCL10 BIRC2 BIRC3 BRME1 C19orf12 CALB1 CALCOCO2 CARD10 CARD11 CARD8 CASP6 CASP8 CCHCR1 CDC37 CDK2 CDKN1A CETN3 CHUK CLIC1 CNOT7 COPS3 CPNE2 CREBBP CUEDC1 CWF19L2 CYLD DAPK1 DDIT3 DDX19B DNAJC8 DYNC1LI1 EEF1A1 EGFR EGLN3 EIF1AX ENKD1 EPHA4 FADD FGR FLT3 FLT4 FRMD8 GADD45G GADD45GIP1 GCC1 GEMIN2 GFAP GIT2 GLO1 GNGT1 GPKOW GRK4 GSK3B GTF2E1 GUCY1A1 GYG2 H1-0 HBZ HCLS1 HDDC2 HIF1A HLA-DQA1 HPCAL1 HPD HSP90AA1 HSP90AB1 HSPA1A HSPA4 ID1 ID3 IFIT5 IKBKB INO80E IRAK1 IRAK4 ITK JAK2 JAK3 KANSL2 KIR3DX1 KRT18 KRT8 LCK LENG8 LGALS2 LMCD1 LPXN LUC7L2 LZIC LZTR1 MACROD1 MAFIP MAP3K14 MAP3K2 MAP3K7 MAPRE1 MCM10 MCM7 MED7 MERTK MLLT6 MPRIP MYD88 MYL5 MYO5C MZT2A NAP1L5 NCOA3 NECAB3 NFKB1 NFKB2 NFKBIA NFKBIB NHP2 NRARP NRBF2 NTMT1 ODAM OSBPL10 OSGIN1 PA2G4 PARP1 PCK1 PDCL PFDN5 PHF7 PIM2 PLEKHJ1 PNMA8A POLR2B POLR2D POLR2E POLR3A PPM1B PRKCB PRKCI PRKCQ PRKD3 PRKN PRPF18 PSMA3 PSMB5 RAB11A RAB11B RAB8A RALBP1 RBBP8 RBM34 RBM8A RBP1 RELA RET RHOA RIPK1 RIPK2 RNF11 RNF4 RNF7 ROR2 ROS1 RPL41 RPS12 RPS6KB2 SCLT1 SENP2 SEPTIN9 SGK1 SHTN1 SLU7 SNW1 SRC SRPK1 SSX2IP STK25 STX11 SUPT5H SYT1 TAB1 TAB2 TAB3 TAF7 TANK TARBP2 TAX1BP1 TBC1D7 TBK1 TCEANC TCP10L TCP11 TCP11L1 TEC TEK TMA16 TNFAIP3 TNFRSF1A TNIP1 TNIP2 TPT1 TRAF3IP2 TRIM29 TRIM31 TRIM37 TRIM41 TRIOBP TRPC4AP TSLP TTYH2 TUBG1 TXLNA TYRO3 UBASH3A UBB UBC UBE2D3 UBE2D4 UBE2I USP10 USP2 VAMP3 WDR5 WWP1 ZBTB3 ZC3H12A ZFAND5 ZNF587 ZNF835 ZZZ3	67 interacting genes: AKTIP BBS10 BCL10 CARD11 CHUK COPS5 CYLD EIF2AK2 ELP1 EZH2 FOS GPR25 HGS HIPK2 IKBKB IKBKG IL17RD IRAK1 MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS MUL1 NAIP NDUFS6 NFKBIA NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB TAB1 TAB2 TAB3 TGFBR1 TNFRSF11A TRAF3 TRAF3IP2 TRAF6 UBASH3A UBC VRK2 XIAP ZNF593 ZNF746
Entrez ID		8517	6885
HPRD ID		02217	04011
Ensembl ID		ENSG00000269335	ENSG00000135341
Uniprot IDs		A0A087X1B1 Q9Y6K9	O43318
PDB IDs		2JVX 2JVY 3BRT 3BRV 3CL3 3FX0 4BWN 5AAY 5LDE 6MI3 6MI4	2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N
Enriched GO Terms of Interacting Partners?
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