PEX3 and SHANK2

Data Source:
BioGRID (genetic interference)

		PEX3	SHANK2
Description		peroxisomal biogenesis factor 3	SH3 and multiple ankyrin repeat domains 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Cytosol Membrane Protein-containing Complex Protein-lipid Complex	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding Lipid Binding Protein-macromolecule Adaptor Activity	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Peroxisome Organization Peroxisome Membrane Biogenesis Protein Import Into Peroxisome Membrane Transmembrane Transport	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		ABC transporters in lipid homeostasis Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Skin aging measurement ( 31522824)	Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		2 interacting genes: PEX16 PEX19	19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		8504	22941
HPRD ID		04407	04479
Ensembl ID		ENSG00000034693	ENSG00000162105
Uniprot IDs		P56589	A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8
PDB IDs		3AJB 3MK4
Enriched GO Terms of Interacting Partners?
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