USP45 and SPDL1

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		USP45	SPDL1
Description		ubiquitin specific peptidase 45	spindle apparatus coiled-coil protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Nucleus Nucleoplasm Cytoplasm	Spindle Pole Condensed Chromosome Outer Kinetochore Nucleus Microtubule Organizing Center Cytosol
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding	Protein Binding Enzyme Binding Kinetochore Binding
	Biological Process	Neural Retina Development DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Migration Protein Deubiquitination Protein Phosphopantetheinylation Photoreceptor Cell Maintenance Global Genome Nucleotide-excision Repair	Establishment Of Mitotic Spindle Orientation Mitotic Metaphase Plate Congression Mitotic Spindle Assembly Checkpoint Cell Migration Protein Localization To Kinetochore Cell Division
Pathways		Formation of Incision Complex in GG-NER	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Erectile dysfunction ( 30297428) Pursuit maintenance gain ( 29064472)
Interacting Genes		7 interacting genes: BMPR1B ERCC1 SMAD1 SMURF1 SPDL1 TGFBR1 UBC	10 interacting genes: CA8 CEP126 DNAAF4 GPS2 ITSN1 PPP1R18 RTP5 TRAF4 USP15 USP45
Entrez ID		85015	54908
HPRD ID		11667	08623
Ensembl ID		ENSG00000123552	ENSG00000040275
Uniprot IDs		D6RBV3 Q70EL2	Q96EA4
PDB IDs
Enriched GO Terms of Interacting Partners?
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