PARP10 and H3-3A

Data Source:
HPRD (in vitro)

		PARP10	H3-3A
Description		poly(ADP-ribose) polymerase family member 10	H3.3 histone A
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Golgi Apparatus Cytosol	Nuclear Chromosome Chromosome, Telomeric Region Nucleosome Barr Body Extracellular Region Nucleus Nucleoplasm Protein-containing Complex Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Protein ADP-ribosylase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Protein ADP-ribosylation Negative Regulation Of Gene Expression Regulation Of Chromatin Assembly Translesion Synthesis Negative Regulation Of NF-kappaB Transcription Factor Activity NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Negative Regulation Of Viral Genome Replication Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Fibroblast Proliferation Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation Negative Regulation Of Protein K63-linked Ubiquitination	RDNA Heterochromatin Assembly Osteoblast Differentiation Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Nucleus Organization Spermatid Development Single Fertilization Embryo Implantation Blood Coagulation Cell Population Proliferation Male Gonad Development Positive Regulation Of Cell Growth Pericentric Heterochromatin Assembly Subtelomeric Heterochromatin Assembly Telomere Organization Multicellular Organism Growth Muscle Cell Differentiation Cellular Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Oogenesis Regulation Of Gene Silencing By MiRNA Regulation Of Centromere Complex Assembly Negative Regulation Of Chromosome Condensation
Pathways		Nicotinamide salvaging Maturation of nucleoprotein Maturation of nucleoprotein	Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Red cell distribution width ( 32888494)
Interacting Genes		12 interacting genes: AURKA H2AC20 H2BC21 H3-3A H3C1 H4C1 MYC PARP14 PCNA PLK1 RAN UBC	38 interacting genes: ASF1A ASF1B ATRX BPTF BRD7 CARM1 CHD1 CREBBP DAXX DCAF1 EP300 ESR1 HMGB2 HPF1 KAT2B KMT2A MAPK9 NEDD4 NOS3 PARP1 PARP10 PARP2 PELP1 PIM1 PPM1D PPP1CA PPP1CB SET SETD7 SMARCA1 SMARCA4 SMARCA5 SS18 SSRP1 SUPT16H SUV39H1 TLE2 ZMYND11
Entrez ID		84875	3020
HPRD ID		15100	03082
Ensembl ID		ENSG00000178685	ENSG00000163041
Uniprot IDs		B4E0C4 E9PK67 E9PNI7 Q53GL7	B2R4P9 P84243
PDB IDs		2DHX 3HKV 5LX6 6FXI	2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 3WTP 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58 4N4I 4O62 4QQ4 4TMP 4U7T 4W5A 5B32 5B33 5BNV 5BNX 5DWQ 5DX0 5JA4 5JJY 5JLB 5KDM 5X7X 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6HGT 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6J9J 6PZV 6QXZ 6R0C 6RNY 6U04 7A08
Enriched GO Terms of Interacting Partners?
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