HAVCR2 and THG1L

Data Source:
BioGRID (affinity chromatography technology)

		HAVCR2	THG1L
Description		hepatitis A virus cellular receptor 2	tRNA-histidine guanylyltransferase 1 like
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GO Annotations	Cellular Component	Immunological Synapse Early Endosome Cell Surface Integral Component Of Membrane Cell Junction	Mitochondrion Mitochondrial Outer Membrane Cytosol Transferase Complex
	Molecular Function	Protein Binding Metal Ion Binding	TRNA Binding Magnesium Ion Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding TRNA Guanylyltransferase Activity Nucleotidyltransferase Activity Identical Protein Binding
	Biological Process	Adaptive Immune Response Macrophage Activation Involved In Immune Response Natural Killer Cell Tolerance Induction Regulation Of Tolerance Induction Dependent Upon Immune Response Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Inflammatory Response Negative Regulation Of Gene Expression Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-3 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Gram-positive Bacterium Maternal Process Involved In Female Pregnancy Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Defense Response To Bacterium Positive Regulation Of Defense Response To Bacterium Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	TRNA Modification Response To Oxidative Stress TRNA Processing Mitochondrial Fusion Regulation Of Catalytic Activity Protein Homotetramerization TRNA 5'-end Processing Stress-induced Mitochondrial Fusion
Pathways		Interleukin-2 family signaling	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Hypertriglyceridemia ( 23505323) Iris heterochromicity ( 30895295)	Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: APP SEC22A TMEM86A	7 interacting genes: ELMOD1 LNX1 NTAQ1 PLEKHF2 SDCBP TERF1 UBC
Entrez ID		84868	54974
HPRD ID		16227	13726
Ensembl ID		ENSG00000135077	ENSG00000113272
Uniprot IDs		Q8TDQ0	B4E366 Q9H8R6 Q9NWX6
PDB IDs		5DZL 5F71 6DHB 6TXZ	3OTB 3OTC 3OTD 3OTE
Enriched GO Terms of Interacting Partners?
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