HAVCR2 and PWWP2A

Data Source:
BioGRID (affinity chromatography technology)

		HAVCR2	PWWP2A
Description		hepatitis A virus cellular receptor 2	PWWP domain containing 2A
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Early Endosome Cell Surface Integral Component Of Membrane Cell Junction	Nucleus
	Molecular Function	Protein Binding Metal Ion Binding	Chromatin Binding Protein Binding Histone Binding
	Biological Process	Adaptive Immune Response Macrophage Activation Involved In Immune Response Natural Killer Cell Tolerance Induction Regulation Of Tolerance Induction Dependent Upon Immune Response Negative Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Inflammatory Response Negative Regulation Of Gene Expression Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interferon-alpha Production Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-3 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-4 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Natural Killer Cell Activation Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Macrophage Activation Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Gram-positive Bacterium Maternal Process Involved In Female Pregnancy Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Negative Regulation Of Granulocyte Colony-stimulating Factor Production Negative Regulation Of Defense Response To Bacterium Positive Regulation Of Defense Response To Bacterium Positive Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways		Interleukin-2 family signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Hypertriglyceridemia ( 23505323) Iris heterochromicity ( 30895295)
Interacting Genes		3 interacting genes: APP SEC22A TMEM86A	1 interacting genes: PLEKHF2
Entrez ID		84868	114825
HPRD ID		16227	19469
Ensembl ID		ENSG00000135077	ENSG00000170234
Uniprot IDs		Q8TDQ0	Q96N64
PDB IDs		5DZL 5F71 6DHB 6TXZ
Enriched GO Terms of Interacting Partners?
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