IRS4 and SOCS6

Data Source:
HPRD (in vitro)

		IRS4	SOCS6
Description		insulin receptor substrate 4	suppressor of cytokine signaling 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Immunological Synapse Cytoplasm Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway	Defense Response Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Proteasomal Protein Catabolic Process Protein Ubiquitination Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation Negative Regulation Of T Cell Activation
Pathways		IRS-related events triggered by IGF1R	Regulation of KIT signaling Neddylation Negative regulation of FLT3
Drugs
Diseases
GWAS			Diverticular disease ( 30177863) Night sleep phenotypes ( 27126917) Systemic lupus erythematosus ( 18204098) Type 2 diabetes ( 29621232)
Interacting Genes		22 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MTNR1A MTNR1B NDN NISCH PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG	39 interacting genes: ACVR1 AMOT APPL1 AR BMPR1B C1orf109 CLNK CRK DAB1 EFEMP1 EGFR ELOB ELOC ERBB2 ERBB3 ERBB4 FRS3 GAB1 INSR IRS2 IRS4 KDM1A KIT LNX1 MET PIK3R1 PIK3R2 PIK3R3 RBCK1 RELA SMURF2 TGFBR1 TUBA1A TUBB4B TXK UBE2D2 UBE2I WDR89 ZMIZ2
Entrez ID		8471	9306
HPRD ID		04620	05491
Ensembl ID		ENSG00000133124	ENSG00000170677
Uniprot IDs		O14654	A0A024R379 O14544
PDB IDs			2VIF
Enriched GO Terms of Interacting Partners?
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