TRIM63 and USP2

Data Source:
BioGRID (enzymatic study)

		TRIM63	USP2
Description		tripartite motif containing 63	ubiquitin specific peptidase 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Z Disc M Band	Nucleoplasm Cytoplasm Centrosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding Titin Binding Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cyclin Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1	Negative Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cell Cycle Muscle Organ Development Protein Deubiquitination Protein Phosphopantetheinylation Circadian Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Locomotor Rhythm Positive Regulation Of Mitotic Cell Cycle Circadian Behavior Protein Stabilization
Pathways		FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)	Refractive error ( 32231278) Serum uric acid levels ( 30993211) Urate levels ( 31985003 31578528 23263486)
Interacting Genes		329 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AGO2 AK1 AKR7A2 ALDOA ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 APP ARL6IP4 ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BAP1 BCAT1 BCHE BRD4 BRWD1 BTBD9 C10orf88 C12orf4 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC130 CCDC28B CDK3 CDS2 CENPK CHMP7 CKB CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DECR2 DEF8 DEK DES DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 ENO3 EPS8L2 ESPL1 EZH2 FAM185A FANK1 FASTKD1 FHL2 FKBP6 FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 HIBADH HID1 HIRA HOXA1 HROB HSPB1 HSPD1 ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 JOSD1 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIAA0825 KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAMA2 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MCM7 MIDN MIIP MKI67 MLH3 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC2 MYBPC3 MYBPHL MYC MYCT1 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NRAP NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF3 PCGF6 PDHB PDK4 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PKM PLEKHG4 PLXNA3 POLR2E PPA2 PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PSMD4 PYGM RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNASEH1 RNF10 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SENP2 SENP3 SET SGCB SHFL SLC6A13 SLFN12 SNAPIN SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 SRF STAM SUMO2 SYMPK SYNCRIP TCAP TCEAL4 TCP10L TEX19 THAP3 THRA TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM35 TRIM41 TRIM54 TRIM55 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UNKL UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YOD1 YPEL3 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16	163 interacting genes: ABI2 ACTN1 ACTN2 ACTN3 APP ASPG ATN1 AURKA BAP1 BCAR1 BCL2L2-PABPN1 BEGAIN BEND5 BHLHB9 BICD2 BIRC7 BRCA1 CADPS CALCOCO2 CARD9 CBLC CCDC136 CCDC57 CCDC85B CCDC88B CCND1 CEP63 CEP70 CRACR2A CRACR2B CRY1 CTNNB1 DDI1 DEPDC5 DISC1 DTX3 DUSP21 DYDC1 EFHC2 EIF4ENIF1 ENPP1 ERBB2 EXOC5 EXOSC8 GEMIN4 GOLGA2 GOLGA6A GOLGA6L9 GRB7 GRIPAP1 H2AC20 HOMER3 HOOK1 HOOK2 IHO1 IKBKG IKZF3 IL1RL2 INTS11 JAKMIP1 JRK KAZN KIFC3 KRT15 KRT27 KRT31 KRT33B KRT34 KRT35 KRT40 LHX3 LHX4 LMNA LMNB2 LNX2 LONRF1 LRSAM1 LZTS2 MALT1 MAP3K2 MDM2 MID2 MNAT1 MORN5 MRPL28 MTUS2 MYC NAB2 NDEL1 NEFL NFKB2 NOTCH1 OIP5 OPTN ORC3 ORC5 PALB2 PCGF6 PCNA PEX5 PIBF1 PICK1 PIK3R3 PLA2G2A PLEKHG4 PNMA1 POU2AF1 PRDM14 PRR5L RABEP1 RAD18 RBCK1 RFX6 RNF125 RNF126 RNF144B RNF166 RUNDC3A S100A10 SH2B2 SNCA SORBS3 SPAG8 SPDYE4 STAT5B TAX1BP1 TEKT4 TFIP11 TGFBR1 TLE5 TNFAIP2 TRAF1 TRAF2 TRAF6 TRAIP TRIM21 TRIM23 TRIM27 TRIM34 TRIM35 TRIM39 TRIM46 TRIM5 TRIM50 TRIM54 TRIM63 TRIM74 TRIM8 TRIM9 TRIP6 UBE2S UBOX5 USHBP1 USP15 USP21 USP54 VCAM1 VPS28 VPS52 ZAP70 ZBED1 ZIM2 ZRANB1
Entrez ID		84676	9099
HPRD ID		05843	05287
Ensembl ID		ENSG00000158022	ENSG00000036672
Uniprot IDs		Q969Q1	O75604
PDB IDs		2D8U 3DDT 4M3L	2HD5 2IBI 3NHE 3V6C 3V6E 5XU8 5XVE 6DGF
Enriched GO Terms of Interacting Partners?
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