DOC2A and EIF3C

Data Source:
BioGRID (genetic interference)

		DOC2A	EIF3C
Description		double C2 domain alpha	eukaryotic translation initiation factor 3 subunit C
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Lysosome Cell Junction Neuron Projection Extrinsic Component Of Synaptic Vesicle Membrane	Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex
	Molecular Function	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Ribosome Binding
	Biological Process	Chemical Synaptic Transmission Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Positive Regulation Of Translation Positive Regulation Of MRNA Binding
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Height ( 28552196) Schizophrenia ( 28991256 25056061 29483656)	Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Extremely high intelligence ( 29520040) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Lamb consumption ( 32066663)
Interacting Genes		5 interacting genes: DYNLT1 RAP1GDS1 STXBP1 UBASH3B UNC13B	19 interacting genes: AAGAB ALKBH4 CALM1 EIF1AX EIF3E EIF3G EIF3J EIF3K ERCC6 HMOX2 MAPK6 NDUFA4L2 PFDN1 PLEKHF2 RPS6KA3 SMAD9 SNIP1 TACC3 TRAPPC2
Entrez ID		8448	8663
HPRD ID		05195	04889
Ensembl ID		ENSG00000149927	ENSG00000184110
Uniprot IDs		Q14183	A0A024QYU9 Q99613
PDB IDs		4MJJ	3J8B 3J8C 6YBD 6YBW 6ZMW 6ZON 6ZP4 7A09
Enriched GO Terms of Interacting Partners?
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