CARD11 and WDR1

Data Source:
HPRD (in vivo)

		CARD11	WDR1
Description		caspase recruitment domain family member 11	WD repeat domain 1
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytoplasm Cytosol Plasma Membrane CBM Complex Membrane Raft Extracellular Exosome	Podosome Extracellular Region Cytosol Plasma Membrane Cell-cell Junction Cell Junction Cortical Actin Cytoskeleton Cell Projection Extracellular Exosome
	Molecular Function	Guanylate Kinase Activity Protein Binding CARD Domain Binding	Actin Filament Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway TORC1 Signaling B Cell Proliferation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process GDP Metabolic Process Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity	Neutrophil Mediated Immunity Platelet Degranulation Sensory Perception Of Sound Regulation Of Cell Shape Actin Filament Depolymerization Actin Filament Fragmentation Platelet Formation Regulation Of Actin Filament Depolymerization Positive Regulation Of Actin Filament Depolymerization Cortical Cytoskeleton Organization Locomotion Establishment Of Planar Polarity Of Follicular Epithelium Apical Junction Assembly Maintenance Of Epithelial Cell Apical/basal Polarity Sarcomere Organization Regulation Of Oligodendrocyte Differentiation Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Neutrophil Migration
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling	Platelet degranulation
Drugs
Diseases
GWAS		Atopic dermatitis ( 23042114) Cadmium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Dupuytren's disease ( 28886342) Intracranial aneurysm ( 29531279) Multiple sclerosis ( 31604244 24076602) Response to fenofibrate (total cholesterol levels) ( 27002377) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)	Atrial fibrillation ( 29892015) Cardiovascular disease risk factors ( 21943158) Cleft plate (environmental tobacco smoke interaction) ( 24516586) Estimated glomerular filtration rate ( 31152163) Pulse pressure ( 30224653) Schizophrenia (age at onset) ( 21688384) Serum uric acid levels ( 32514006) Urate levels ( 18179892 31578528) Uric acid levels ( 22229870)
Interacting Genes		15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70	6 interacting genes: CARD11 CFL1 CSNK2B GRB2 HSPB2 SKIV2L
Entrez ID		84433	9948
HPRD ID		06234	09199
Ensembl ID		ENSG00000198286	ENSG00000071127
Uniprot IDs		A0A024R854 Q8TES3 Q9BXL7	O75083 V9HWG7
PDB IDs		4JUP 4LWD
Enriched GO Terms of Interacting Partners?
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