NCK2 and PRDM6

Data Source:
BioGRID (two hybrid)

		NCK2	PRDM6
Description		NCK adaptor protein 2	PR/SET domain 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane Postsynaptic Density	Nucleus
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding Cytoskeletal Anchor Activity Signaling Receptor Complex Adaptor Activity Signaling Adaptor Activity Protein-containing Complex Binding Scaffold Protein Binding	Protein Binding Methyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Immunological Synapse Formation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Population Proliferation Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Dendritic Spine Development Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Regulation Of Gene Expression Neurogenesis Methylation Negative Regulation Of Smooth Muscle Cell Differentiation
Pathways		Downstream signal transduction Nephrin family interactions Ephrin signaling Activation of RAC1 VEGFA-VEGFR2 Pathway Regulation of cortical dendrite branching
Drugs
Diseases
GWAS		Addiction ( 23533358) Anti-chlamydia trachomatis IgG seropositivity ( 33204752) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494 27863252) Systolic blood pressure in sickle cell anemia ( 24058526)	Body mass index ( 28892062) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 27618447) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Male-pattern baldness ( 28196072) Mammographic density (dense area) ( 25342443) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Percent mammographic density ( 25342443) Pulse pressure ( 27841878 27618447) QRS duration ( 25035420) Systolic blood pressure ( 26390057 27841878 27618447 30578418)
Interacting Genes		171 interacting genes: ABI1 ABI2 ABI3 ANKRD55 ANKS1B ARHGAP32 ATN1 AXIN1 AXL BCAR1 BCL11A BTG1 C4orf17 CBARP CBLB CCDC120 CCDC33 CD3E CHN1 CHN2 CIB1 CIPC CLEC17A CPSF6 CPSF7 CUEDC1 DDR1 DEFB124 DISC1 DLGAP4 DNM1 DOCK1 DOK1 DRAP1 DTX3 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EFS EGFR EIF3H ERBB2 ERBB3 ERBB4 FAM124A FAM47A FAM53C FAM83A FASLG FBXL19 FCRL2 FGFR1 FOSB FXR2 FYB1 GAB1 GAREM1 GGN HNRNPK HOMEZ HOXA1 HOXC4 HOXD8 HSF2BP ILK INCA1 INTS2 IRS1 KCTD17 KHDRBS1 KIAA0408 KIAA1217 KIT KLHL24 KLHL35 KPRP LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MBD6 MEOX2 MET MIA3 MNT MYPOP NCKIPSD NELFA NET1 NFKBID NHSL2 NPAS2 NPHS1 NR5A1 NTRK2 NUTM2F ONECUT3 PAK1 PAK2 PBX4 PDGFRB PHETA1 PIK3AP1 PKD1 PKN2 PRDM6 PRR16 PRR20A PRR20B PRR20C PRR20D PRR20E PSMD10 PTK2 RASSF7 RBBP8NL RBM26 REEP4 REL SCML2 SCX SF1 SF3A2 SF3B4 SHD SKAP2 SMARCB1 SNW1 SOCS7 SORBS2 SOS1 SPATA2L SPATC1L SPRY2 SRMS SRPK1 SRPK2 SSH3 SYNGAP1 SYNPO TCF4 TCP10L TMEM121 TNR TRIM27 TRIM41 TRIP6 TXK UBC USP32 VARS2 VPS37B WAS WASF1 WASL WBP11 WIPF1 WIPF2 ZBTB12 ZBTB42 ZBTB7B ZC2HC1A ZC2HC1B ZNF341 ZNF526 ZNF688	70 interacting genes: ABI2 AGXT AHCYL1 ANKS1A AQP1 ARID5A ATPAF2 ATXN7L2 BAG3 BANF2 BANP C1orf109 CBFA2T2 CBX8 CCDC120 CCDC57 CCHCR1 CCNL1 CEP57L1 COX5B CSTF2 ELOA ENKD1 EXOSC5 FAM214B FAM90A1 FHL2 FOXD4L1 FRS3 FTO GADD45GIP1 GEM GPANK1 GRXCR1 HOXC8 IL16 IQUB KANK2 KAT5 KCTD9 KIFC3 LMO1 LMO2 LONRF1 MYOZ3 NCK2 NEK6 NFKBID PATZ1 PIH1D2 PRKAA2 PTK6 QARS1 RAD51D ROPN1 RUNX1T1 SAMD4A STK16 TCAF1 TEKT4 TLE5 TRIM14 TRMT12 TSGA10 TSGA10IP TSSK3 TTC23 UBASH3A USP54 ZFYVE26
Entrez ID		8440	93166
HPRD ID		05378	19698
Ensembl ID		ENSG00000071051	ENSG00000061455
Uniprot IDs		A0A0S2Z4M6 E7ERP6 O43639	Q9NQX0
PDB IDs		1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?
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