RPAIN and CYP17A1

Data Source:
BioGRID (two hybrid)

		RPAIN	CYP17A1
Description		RPA interacting protein	cytochrome P450 family 17 subfamily A member 1
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm PML Body	Endoplasmic Reticulum Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Protein-containing Complex Binding Metal Ion Binding	Steroid 17-alpha-monooxygenase Activity Iron Ion Binding Oxygen Binding Heme Binding 17-alpha-hydroxyprogesterone Aldolase Activity
	Biological Process	DNA-dependent DNA Replication DNA Repair DNA Recombination Protein Import Into Nucleus	Steroid Biosynthetic Process Androgen Biosynthetic Process Glucocorticoid Biosynthetic Process Sex Differentiation Steroid Metabolic Process Hormone Biosynthetic Process Progesterone Metabolic Process
Pathways			Androgen biosynthesis Glucocorticoid biosynthesis Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
Drugs			NADH Progesterone Spironolactone Ketoconazole Abiraterone Cannabidiol Medical Cannabis Nabiximols
Diseases			46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
GWAS		Body mass index ( 29273807) Menopause (age at onset) ( 26414677) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Birth weight ( 31043758) Blood pressure ( 21572416 24001895 21909110) Brain morphology (MOSTest) ( 32665545) Colorectal cancer ( 26965516) Coronary artery disease ( 32469254 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 21378990) Diastolic blood pressure ( 27841878 28739976 27618452 25249183) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Hip circumference ( 25673412) Hypertension ( 31879980 25249183 30487518) Mean arterial pressure ( 26390057 27618448 30487518) Microalbuminuria ( 26631737) Myocardial infarction ( 26343387) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Pulse pressure ( 27841878 28739976 30487518) Schizophrenia ( 25056061 29483656 23974872) Sodium levels ( 29403010) Systolic blood pressure ( 26390057 27736895 28135244 19430479 19430483 27841878 21909115 28739976 27618447 27618452 25249183 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Waist circumference ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		7 interacting genes: ADH6 CDCA5 CLNK CYP17A1 GSTA1 RAD51B TNS4	15 interacting genes: APC ATP5F1E BARX1 CDO1 CHEK2 CYB5A ERBB2 FZR1 HSP90AB1 IGF1R POR PTPRJ RPAIN STK11 TIGD7
Entrez ID		84268	1586
HPRD ID		14615	01944
Ensembl ID		ENSG00000129197	ENSG00000148795
Uniprot IDs		B3KTT3 Q86UA6	P05093 Q1HB44
PDB IDs			2C17 3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY 4NKZ 5IRQ 5IRV 5UYS 6CHI 6CIR 6CIZ
Enriched GO Terms of Interacting Partners?
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