CASP9 and CARD8

Data Source:
HPRD (in vivo, in vitro)

		CASP9	CARD8
Description		caspase 9	caspase recruitment domain family member 8
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GO Annotations	Cellular Component	Cytoplasm Cytosol Protein-containing Complex Apoptosome	Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Inflammasome Complex NLRP3 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity SH3 Domain Binding Protein Kinase Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process NACHT Domain Binding Protein Homodimerization Activity CARD Domain Binding
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Platelet Formation Cellular Response To UV Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Regulation Of Response To DNA Damage Stimulus	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inhibition Of Cysteine-type Endopeptidase Activity
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity Regulation of the apoptosome activity	Formation of apoptosome Regulation of the apoptosome activity
Drugs		Pamidronic acid
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		47 interacting genes: ABL1 AKT1 APAF1 ARNT BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP12 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HECTD3 HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP	9 interacting genes: CARD16 CARD18 CASP1 CASP9 FHL2 IKBKG MTDH NLRP2 NLRP3
Entrez ID		842	22900
HPRD ID		03756	16425
Ensembl ID		ENSG00000132906	ENSG00000105483
Uniprot IDs		F8VVS7 P55211	A0A024QZD3 E5RFV9 Q9Y2G2
PDB IDs		1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW 5JUY 5WVC 5WVE	4IKM 6K9F
Enriched GO Terms of Interacting Partners?
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