PLA2G10 and KRTAP26-1

Data Source:
BioGRID (two hybrid)

		PLA2G10	KRTAP26-1
Description		phospholipase A2 group X	keratin associated protein 26-1
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Lysosome	Cytosol Intermediate Filament
	Molecular Function	1-alkyl-2-acetylglycerophosphocholine Esterase Activity Phospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Protein Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylserine Metabolic Process Axon Guidance Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Arachidonic Acid Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Prostaglandin Secretion Low-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Cholesterol Homeostasis Regulation Of Macrophage Activation Negative Regulation Of DNA-binding Transcription Factor Activity Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Phosphatidic Acid Metabolic Process Arachidonic Acid Secretion Defense Response To Virus Lysophospholipid Transport Platelet Activating Factor Catabolic Process Positive Regulation Of Arachidonic Acid Secretion Negative Regulation Of Cholesterol Efflux Positive Regulation Of Acrosome Reaction	Keratinization
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA	Keratinization
Drugs		Varespladib methyl Crotalus adamanteus antivenin Agkistrodon piscivorus antivenin
Diseases
GWAS		Cholesteryl ester levels ( 31551469) Glycerophospholipid levels ( 26068415)
Interacting Genes		49 interacting genes: AGXT AQP1 ARID5A ATXN1 BAG3 BEX2 C1orf94 CATSPER1 CCDC120 CREB5 CYSRT1 FAM222B FOXH1 GATA5 GNE HGS HOXC8 HR HSF4 INCA1 KPRP KRTAP11-1 KRTAP26-1 LCE1A LCE1C LCE2A LCE2B LCE2D MAL MAPKBP1 MGAT5B MYO10 NOXA1 NTAQ1 OTX1 PITX1 PLA2R1 POU4F3 PPP1R32 ROR2 SNRPC SPAG8 STK16 TBX6 TFG TLX3 VGLL3 VPS37C ZC3H10	91 interacting genes: ACY3 ARID5A C19orf54 CARD10 CCNJL CELF5 CERCAM CFAP206 COL8A1 CYSRT1 DAZAP2 DTX2 EFEMP2 FAM168B FAM222B GDPD5 GRN HGS HNF1B HOXA1 ID3 INTS11 KRT34 KRTAP1-1 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP13-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-7 KRTAP5-6 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP8-1 KRTAP9-2 KRTAP9-8 LASP1 LCE2B MAPKBP1 MGAT5B NBPF19 NHLRC4 NOTCH2NLA OTX1 PITX1 PLA2G10 PM20D2 PRR22 PRR35 PSMA3 RASD1 RBPMS RECK RHOXF2 RNF208 SF1 SIVA1 SLC15A2 SMARCC1 SMUG1 SPAG8 SPATA12 SSC4D STK16 TEKT3 TEKT4 TENT5A TEX37 TFAP2D TFG TOX TRIM42 TRIP13 TRIP6 VASN VENTX YTHDF1 ZNF34
Entrez ID		8399	388818
HPRD ID		04674	14206
Ensembl ID		ENSG00000069764	ENSG00000197683
Uniprot IDs		O15496	Q6PEX3
PDB IDs		1LE6 1LE7 4UY1 5G3M 5OW8 5OWC 6G5J
Enriched GO Terms of Interacting Partners?
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