KRTAP1-5 and CRH

Data Source:
BioGRID (two hybrid)

		KRTAP1-5	CRH
Description		keratin associated protein 1-5	corticotropin releasing hormone
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Keratin Filament	Extracellular Region Extracellular Space Cytoplasm Varicosity Perikaryon Synapse
	Molecular Function	Molecular_function Protein Binding	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Corticotropin-releasing Hormone Activity Corticotropin-releasing Hormone Receptor 1 Binding Corticotropin-releasing Hormone Receptor 2 Binding
	Biological Process	Biological_process Keratinization	Positive Regulation Of Protein Phosphorylation Synaptic Transmission, Dopaminergic Negative Regulation Of Systemic Arterial Blood Pressure Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Female Pregnancy Parturition Learning Or Memory Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Associative Learning Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Norepinephrine Secretion Positive Regulation Of Circadian Sleep/wake Cycle, Wakefulness Positive Regulation Of Cell Death Regulation Of Serotonin Secretion Diterpenoid Metabolic Process Hypothalamus Development Negative Regulation Of Epinephrine Secretion Negative Regulation Of Luteinizing Hormone Secretion Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Response To Immobilization Stress Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep Response To Drug Response To Estrogen Positive Regulation Of CAMP-mediated Signaling Response To Ethanol Response To Ether Response To Pain Ion Homeostasis Response To Corticosterone Positive Regulation Of Corticotropin Secretion Positive Regulation Of Cortisol Secretion Long-term Synaptic Potentiation Positive Regulation Of Digestive System Process Negative Regulation Of Cell Death Negative Regulation Of Glucagon Secretion Cellular Response To Cocaine Cellular Response To Dexamethasone Stimulus Positive Regulation Of Calcium Ion Import Regulation Of NMDA Receptor Activity Positive Regulation Of Corticosterone Secretion Positive Regulation Of Behavioral Fear Response
Pathways		Keratinization	Class B/2 (Secretin family receptors) G alpha (s) signalling events MECP2 regulates transcription of neuronal ligands ADORA2B mediated anti-inflammatory cytokines production
Drugs			Corticotropin D-Phenylalanine 2-aminoisobutyric acid
Diseases
GWAS			Adult body size ( 32376654) Coronary heart disease event reduction (statin therapy interaction) ( 22666496)
Interacting Genes		37 interacting genes: ADAMTSL4 AQP1 CATSPER1 CREB5 CRH CYSRT1 DMRT3 FAM124B GRN GUCD1 HOXA1 HOXB9 KPRP KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP9-2 LCE1B LCE1D LCE1E LCE2B LCE2D LCE3A LCE3D LCE4A LCE5A NMU NUFIP2 OTX1 PLSCR4 SDCBP SHFL SMCP WNT11 YY1	12 interacting genes: CRHR1 CRHR2 CYSRT1 KRT31 KRTAP1-3 KRTAP1-5 KRTAP10-8 KRTAP5-9 KRTAP9-3 MDFI NBPF19 NOTCH2NLA
Entrez ID		83895	1392
HPRD ID		12306	07172
Ensembl ID		ENSG00000221852	ENSG00000147571
Uniprot IDs		Q9BYS1	A0A0S2Z478 P06850
PDB IDs			1GO9 1GOE 3EHT 3EHU 6P9X
Enriched GO Terms of Interacting Partners?
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