USHBP1 and COPS6

Data Source:
BioGRID (two hybrid)

		USHBP1	COPS6
Description		USH1 protein network component harmonin binding protein 1	COP9 signalosome subunit 6
Image		No pdb structure
GO Annotations	Cellular Component		Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding PDZ Domain Binding	Protein Binding Metallopeptidase Activity Isopeptidase Activity
	Biological Process		Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Viral Process Post-translational Protein Modification
Pathways			DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Mitochondrial DNA copy number ( 30704525)	Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		234 interacting genes: ABHD11 ABI2 ABLIM1 ACMSD AKAP9 ANKRD33 ANKRD36BP1 ARFIP2 ARMC5 ARNT2 ASB15 ATP5PO BCAS2 BCL10 BCL2L11 BET1 BEX2 BEX3 BFSP1 BFSP2 BICRAL BLOC1S1 BLZF1 BORCS6 BRAT1 BRPF1 C1orf109 C1orf216 C21orf58 CBY2 CCDC103 CCDC116 CCDC120 CCDC121 CCDC146 CCDC148 CCDC187 CCDC196 CCDC197 CCDC22 CCDC24 CCDC28A CCDC33 CCDC42 CCDC87 CCHCR1 CCNK CDC37 CDC5L CDKN1A CENPP CEP63 CEP68 CFAP206 CHCHD3 CNNM3 COPS4 COPS6 COPS8 CTNNA3 CTNNBIP1 CTTNBP2NL CYTH4 DCTN2 DCTN3 DEPP1 DEUP1 DTNB DYDC1 EIF4E2 ENKD1 ERCC1 EXOC7 EXOC8 FAM107A FAM110A FAM124B FAM161B FANCG FATE1 FBF1 FCHSD2 FCRL5 FTL GAS8 GATAD2B GCC1 GEM GFI1B GIT2 GMCL2 GNG4 GOLGA6L9 GOLGA8EP GOLGA8F GPSM1 GPSM3 GTF2H1 HAUS1 HAUS8 HGS HMG20A HMG20B HYI IFT20 IL16 IMP3 ING3 INPP1 INTS4 ITGB3BP KANK2 KANSL1 KIAA0753 KLC3 KLC4 KLHL38 KLHL42 KPNA2 KRT14 KRT15 KRT16 KRT19 KRT20 KRT26 KRT27 KRT28 KRT31 KRT37 KRT38 KRT40 KRT71 KRT75 KRT79 LENG1 LINC00526 MAGEB4 MCCD1 MCM7 MCRS1 MED11 MED28 MED4 MEI4 METTL15 MIIP MKRN3 MNS1 MOS MRPS23 MXI1 MYOG MYOZ1 NCAPH2 NDC80 NDE1 NECAB2 NEFL NOC4L NUP62 ODAD3 OIP5 PARVG PAX6 PBX4 PICK1 PKN1 PKNOX2 PMF1 POLM POP5 PPP1R12C PPP1R7 PPP2R5A PPP2R5D PRC1 PRKAA2 PRR5 QARS1 RASAL2 RCOR3 RECK RIBC1 RIBC2 RINT1 RNF20 RTP5 SAPCD2 SAT1 SCNM1 SCT SEC14L4 SEMA4C SERTAD3 SH2D4A SHC3 SMARCD1 SMARCE1 SOHLH1 SPG21 SRI STX11 SYNJ2BP TASOR2 TCEANC TCHP TEKT1 THADA THOC1 TIMM13 TPRX1 TRIM54 TRIML2 TSG101 TTC23 TTC9C TTLL10 TUBGCP4 TXLNA TXLNB UBE2W UBXN11 USH1C USP2 VPS28 ZBTB42 ZFHX3 ZFYVE26 ZNF417 ZNF483 ZNF655 ZNF688 ZNF765 ZNRF2P1	93 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS7B COPS8 COPS9 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHC3 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24
Entrez ID		83878	10980
HPRD ID		18276	16735
Ensembl ID		ENSG00000130307	ENSG00000168090
Uniprot IDs		A0A024R7H3 B4DUE8 G8JLM4 Q8N6Y0 Q8N8Y1	Q7L5N1
PDB IDs			4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I
Enriched GO Terms of Interacting Partners?
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