CASP2 and MZB1

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CASP2	MZB1
Description		caspase 2	marginal zone B and B1 cell specific protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Membrane	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Chaperone Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Protein Binding
	Biological Process	Luteolysis Neural Retina Development Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Brain Development Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing Ectopic Germ Cell Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway	Positive Regulation Of Immunoglobulin Production Apoptotic Process Positive Regulation Of Cell Population Proliferation Regulation Of B Cell Proliferation Integrin Activation Regulation Of Cell Population Proliferation Regulation Of Insulin Receptor Signaling Pathway
Pathways		NOD1/2 Signaling Pathway NADE modulates death signalling TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS			Body mass index ( 26426971) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Malaria ( 31844061)
Interacting Genes		31 interacting genes: ADCYAP1 BAG4 BID CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 PRKAB2 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I	4 interacting genes: CASP2 CASP9 MAPK6 TSG101
Entrez ID		835	51237
HPRD ID		02800	17815
Ensembl ID		ENSG00000106144	ENSG00000170476
Uniprot IDs		A0A087WYM1 A0A0S2Z3H1 D3DXD9 P42575	Q8WU39
PDB IDs		1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM 6GKF 6GKG 6S9K 6SAD
Enriched GO Terms of Interacting Partners?
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