CDC7 and DTD1

Data Source:
BioGRID (enzymatic study)

		CDC7	DTD1
Description		cell division cycle 7	D-aminoacyl-tRNA deacylase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle	Nucleus Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	TRNA Binding DNA Binding Metal Ion Binding D-tyrosyl-tRNA(Tyr) Deacylase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division Negative Regulation Of G0 To G1 Transition	DNA Replication TRNA Metabolic Process Aminoacyl-tRNA Metabolism Involved In Translational Fidelity
Pathways		Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Plateletcrit ( 32888494) PR interval ( 32439900) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Alcohol consumption (drinks per week) ( 30679032) Bitter alcoholic beverage consumption ( 31046077) C-reactive protein (red blood cell fatty acid level interaction) ( 28820441) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		52 interacting genes: APP BANP CALCOCO2 CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN DBF4 DBF4B DIAPH1 DTD1 FXR1 GMEB2 GOLGA2 GOLGA6A GPT GRHPR HMBOX1 HOMEZ IKZF1 IKZF3 IKZF4 LZTS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MEOX2 MTUS2 NDUFB2 ORC1 ORC5 ORC6 PGK1 SERTAD2 STAM2 TMBIM6 TOB1 TRIM27 TRIM37 TSNAXIP1 TSPY10 TSPY3 ZBTB10 ZBTB26 ZBTB8B	4 interacting genes: CDC7 CSNK2A1 NR3C1 PTPA
Entrez ID		8317	92675
HPRD ID		10345	13631
Ensembl ID		ENSG00000097046	ENSG00000125821
Uniprot IDs		A0A384MTU6 B2R6V2 O00311	A0A2R8Y6X2 Q8TEA8
PDB IDs		4F99 4F9A 4F9B 4F9C 5UWQ 5UWR 6YA6 6YA7 6YA8	2OKV
Enriched GO Terms of Interacting Partners?
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