BRAP and BRK1

Data Source:
BioGRID (two hybrid)

		BRAP	BRK1
Description		BRCA1 associated protein	BRICK1 subunit of SCAR/WAVE actin nucleating complex
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Cytosol Nuclear Membrane	Cytosol Cytoskeleton Lamellipodium SCAR Complex Extracellular Exosome
	Molecular Function	Nucleic Acid Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination	In Utero Embryonic Development Actin Filament Organization Regulation Of Actin Polymerization Or Depolymerization Positive Regulation Of Cell Population Proliferation Positive Regulation Of Lamellipodium Assembly Rac Protein Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		RAF activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence ( 31591379) Alcohol dependence symptom count ( 29460428) Alcohol use disorder (consumption score) ( 30940813) Asthma ( 30929738 32296059) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blood protein levels ( 29875488) Body mass index ( 26426971 25673413) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Coffee consumption ( 29367735) Colorectal cancer ( 26151821) Crohn's disease ( 28067908) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Drinking behavior ( 21372407) Esophageal cancer ( 19698717) Gastroesophageal reflux disease ( 31527586) Hematological and biochemical traits ( 20139978) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypothyroidism ( 22493691) Inflammatory bowel disease ( 28067908) LDL cholesterol ( 24097068 20686565) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myocardial infarction ( 30226566) Parental lifespan ( 30642433) Platelet count ( 27863252) Plateletcrit ( 27863252) Primary biliary cirrhosis ( 22961000) Psoriasis ( 25854761 28537254) Response to alcohol consumption (flushing response) ( 29460428) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum folate levels ( 29953918) Serum uric acid levels ( 29124443) Small vessel stroke (CCSp classification) ( 32047268) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Tumor necrosis factor levels ( 32805626)	Arterial stiffness index ( 31235810)
Interacting Genes		41 interacting genes: AKAP3 APOA1 ATMIN BRCA1 BRK1 CCDC105 CCDC30 CDC14A CENPF CNKSR1 DDB1 DNMT1 FAM184A FBXO2 HMG20A HRAS KSR1 LINC00852 NUMA1 PHLPP1 RBM12 SHCBP1L SKP2 SMARCE1 SYNE2 TANC2 TEX35 TRIM41 TRIM55 TRIM8 UBB UBC UBE2D2 UBE2H UBE2L3 USP15 USP4 YJU2 ZNF382 ZNF479 ZNF521	10 interacting genes: BRAP CYFIP2 HSBP1 MRFAP1 NCK1 NCKAP1 NDEL1 PFDN1 PIK3R3 WASF1
Entrez ID		8315	55845
HPRD ID		05405	12818
Ensembl ID		ENSG00000089234	ENSG00000254999
Uniprot IDs		Q59H81 Q7Z569	Q8WUW1
PDB IDs			3P8C 4N78
Enriched GO Terms of Interacting Partners?
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