BAP1 and BCAR3

Data Source:
BioGRID (two hybrid)

		BAP1	BCAR3
Description		BRCA1 associated protein 1	BCAR3 adaptor protein, NSP family member
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PR-DUB Complex	Cytoplasm Focal Adhesion Membrane
	Molecular Function	Chromatin Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Kinase Binding
	Biological Process	Regulation Of Cell Growth Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Response To Inorganic Substance Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Negative Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Regulation Of Cell Cycle Macrophage Homeostasis Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion	Lens Morphogenesis In Camera-type Eye Signal Transduction Small GTPase Mediated Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Peptidyl-serine Phosphorylation Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of GTPase Activity Positive Regulation Of DNA Replication Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Endothelin Receptor Signaling Pathway
Pathways		UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Alzheimer's disease progression score ( 29860282) Blood urea nitrogen levels ( 31152163) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Liver fibrosis (total hepatic collagen content) ( 32953199) Major depressive disorder ( 27777418) Systolic blood pressure ( 30224653)
Interacting Genes		27 interacting genes: BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 IGF1R ITPR3 KLF5 LINC00598 MAP3K1 NBN PTPRJ RB1CC1 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1	38 interacting genes: AGR3 AP1M1 APP ATAD2 BAP1 BEX1 BEX2 CASZ1 CCDC57 CCL5 CST6 DKK3 EGFR EPSTI1 ERBB2 ERBB3 ERBB4 ERRFI1 GAB1 GAS8 GLCE GREB1 HOXC6 KIT KPNA1 MET MTA3 NEDD9 NSD3 OSGIN1 PDLIM2 PRDM14 PSMC3IP RPRD1A SERPINB5 THRSP UBASH3A VPS45
Entrez ID		8314	8412
HPRD ID		04366	05268
Ensembl ID		ENSG00000163930	ENSG00000137936
Uniprot IDs		A0A024R305 F8W6N3 Q92560	A0A384MTS3 B3KNL6 B3KP06 O75815
PDB IDs			3T6A
Enriched GO Terms of Interacting Partners?
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