CAPZA2 and CAPZA3

Data Source:
HPRD (in vitro)

		CAPZA2	CAPZA3
Description		capping actin protein of muscle Z-line subunit alpha 2	capping actin protein of muscle Z-line subunit alpha 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Brush Border F-actin Capping Protein Complex Actin Cytoskeleton Membrane Cortical Cytoskeleton Extracellular Exosome	Nucleus Cytosol F-actin Capping Protein Complex Membrane Cortical Cytoskeleton Sperm Head
	Molecular Function	Protein Binding Actin Filament Binding	Actin Filament Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Actin Cytoskeleton Organization Innate Immune Response Barbed-end Actin Filament Capping Protein-containing Complex Assembly	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Actin Filament Organization Cytoplasm Organization Spermatid Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Actin Cytoskeleton Organization Barbed-end Actin Filament Capping
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Pulse pressure ( 27841878) Triglyceride levels ( 32203549 32154731) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Daytime sleep phenotypes ( 27126917) Personality dimensions ( 23903073)
Interacting Genes		3 interacting genes: CAPZA3 HSPB2 RBBP6	2 interacting genes: ACTG1 CAPZA2
Entrez ID		830	93661
HPRD ID		11871	12282
Ensembl ID		ENSG00000198898	ENSG00000177938
Uniprot IDs		A4D0V4 P47755	A0A140VKF6 Q96KX2
PDB IDs
Enriched GO Terms of Interacting Partners?
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