CANX and EDEM1

Data Source:
HPRD (in vivo)

		CANX	EDEM1
Description		calnexin	ER degradation enhancing alpha-mannosidase like protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Melanosome Mitochondria-associated Endoplasmic Reticulum Membrane Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Presynapse	Endoplasmic Reticulum Aggresome Integral Component Of Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding Carbohydrate Binding Unfolded Protein Binding	Mannosyl-oligosaccharide 1,2-alpha-mannosidase Activity Calcium Ion Binding Protein Binding Misfolded Protein Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Folding Protein Secretion Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Endoplasmic Reticulum Unfolded Protein Response Protein Folding In Endoplasmic Reticulum Synaptic Vesicle Endocytosis Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Clathrin-dependent Endocytosis	Carbohydrate Metabolic Process Ubiquitin-dependent ERAD Pathway IRE1-mediated Unfolded Protein Response Trimming Of Terminal Mannose On C Branch Protein Targeting To ER Ubiquitin-dependent Glycoprotein ERAD Pathway Positive Regulation Of Retrograde Protein Transport, ER To Cytosol Mannose Trimming Involved In Glycoprotein ERAD Pathway
Pathways		Assembly of Viral Components at the Budding Site MHC class II antigen presentation Interleukin-35 Signalling Calnexin/calreticulin cycle Interleukin-27 signaling Maturation of spike protein Maturation of spike protein Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	XBP1(S) activates chaperone genes ER Quality Control Compartment (ERQC)
Drugs		Antihemophilic factor, human recombinant Tenecteplase Lanoteplase Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Resting heart rate ( 24680774) White blood cell count ( 32888494 27863252)	Diverticular disease ( 30177863) Metabolite levels ( 23823483) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Uterine fibroids ( 28836065)
Interacting Genes		47 interacting genes: ABCC2 APOB BCAP31 CD1D CD3D CD82 CFTR CSNK2A1 EBI3 EDEM1 F2RL1 F8 FAM107A FSHR GPR35 GRIA1 GRIN1 HLA-A HTR3A IFNGR1 ITGA6 ITGB1 LCT LHCGR LINC01554 LPA LRP1 LTB4R2 MBTPS1 MDM2 MTNR1A MTNR1B NDRG1 PDIA3 PLP1 PMP22 PRKCSH SERP1 SLC2A1 SLC4A1 SLC6A4 SMURF2 SUMO1 TF TG TRA TSHR	1 interacting genes: CANX
Entrez ID		821	9695
HPRD ID		00252	09644
Ensembl ID		ENSG00000127022	ENSG00000134109
Uniprot IDs		P27824	A0A024R2D5 Q92611
PDB IDs
Enriched GO Terms of Interacting Partners?
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