SHARPIN and PPIL3

Data Source:
BioGRID (pull down)

		SHARPIN	PPIL3
Description		SHANK associated RH domain interactor	peptidylprolyl isomerase like 3
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Dendrite LUBAC Complex	Catalytic Step 2 Spliceosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding
	Biological Process	Mitochondrion Organization I-kappaB Kinase/NF-kappaB Signaling Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway	MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding
Pathways		Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		21 interacting genes: ACTR2 ACTR3 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 SHANK1 SHANK2 TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32	6 interacting genes: CENATAC PCBP1 SHARPIN SLU7 TAB2 TAB3
Entrez ID		81858	53938
HPRD ID		15463	15163
Ensembl ID		ENSG00000179526	ENSG00000240344
Uniprot IDs		Q6PJD5 Q9H0F6	A0A024R3V4 A0A0S2Z5A8 Q9H2H8
PDB IDs		4EMO 5X0W	1XYH 2OJU 2OK3
Enriched GO Terms of Interacting Partners?
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